ADAP1

ADAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3FEH, 3FM8, 3LJU, 3MDB
Dynodwyr
Cyfenwau	ADAP1, CENTA1, GCS1L, p42IP4, Centaurin, alpha 1, ArfGAP with dual PH domains 1
Dynodwyr allanol	OMIM: 608114 HomoloGene: 55997 GeneCards: ADAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • metal ion binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • inositol 1,3,4,5 tetrakisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol bisphosphate binding Cydrannau o'r gell • cytoplasm • Cellbilen • cnewyllyn cell • cytosol Prosesau biolegol • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • cell surface receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11033	n/a
Ensembl	ENSG00000105963	n/a
UniProt	O75689	n/a
RefSeq (mRNA)	NM_006869 NM_001284308 NM_001284309 NM_001284310 NM_001284311	n/a
RefSeq (protein)	NP_001271237 NP_001271238 NP_001271239 NP_001271240 NP_006860	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAP1 yw ADAP1 a elwir hefyd yn Arf-GAP with dual PH domain-containing protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAP1.

• GCS1L
• CENTA1
• p42IP4

Llyfryddiaeth

• "Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin. ". Neuroreport. 2004. PMID 15106847.
• "Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells. ". Brain Res Mol Brain Res. 2002. PMID 11869802.
• "Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1. ". Biol Chem. 2014. PMID 24854535.
• "Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity. ". J Neurochem. 2006. PMID 16805830.
• "Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization.". Mol Pharmacol. 2005. PMID 15778454.