ADAP1

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ADAP1
Protein ADAP1 PDB 3FEH.png
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauADAP1, CENTA1, GCS1L, p42IP4, Centaurin, alpha 1, ArfGAP with dual PH domains 1
Dynodwyr allanolMGI: 2442201 HomoloGene: 55997 GeneCards: ADAP1
Patrwm RNA pattern
PBB GE CENTA1 90265 at fs.png

PBB GE CENTA1 219150 s at fs.png

PBB GE CENTA1 gnf1h04681 s at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006869
NM_001284308
NM_001284309
NM_001284310
NM_001284311

NM_172723

RefSeq (protein)

NP_001271237
NP_001271238
NP_001271239
NP_001271240
NP_006860

n/a

Lleoliad (UCSC)n/aChr : 139.27 – 139.33 Mb
PubMed search[2][3]
Wicidata
Gweld/Golygu Bod dynolGweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAP1 yw ADAP1 a elwir hefyd yn Arf-GAP with dual PH domain-containing protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p22.3.[4]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAP1.

  • GCS1L
  • CENTA1
  • p42IP4

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin. ". Neuroreport. 2004. PMID 15106847.
  • "Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells. ". Brain Res Mol Brain Res. 2002. PMID 11869802.
  • "Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1. ". Biol Chem. 2014. PMID 24854535.
  • "Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity. ". J Neurochem. 2006. PMID 16805830.
  • "Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization.". Mol Pharmacol. 2005. PMID 15778454.

Cyfeiriadau[golygu | golygu cod y dudalen]