ABCC1

ABCC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CBZ, 4C3Z
Dynodwyr
Cyfenwau	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1, ATP binding cassette subfamily C member 1, DFNA77
Dynodwyr allanol	OMIM: 158343 HomoloGene: 133779 GeneCards: ABCC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ATPase-coupled transmembrane transporter activity • nucleotide binding • ATPase activity • hydrolase activity • ATP binding • transporter activity • ATPase-coupled inorganic anion transmembrane transporter activity • GO:0102023, GO:0015235 ABC-type vitamin B12 transporter activity • ABC-type xenobiotic transporter activity • ABC-type glutathione S-conjugate transporter activity • glutathione transmembrane transporter activity • GO:0004012 ATPase-coupled intramembrane lipid transporter activity • sphingolipid floppase activity • GO:0022891 transmembrane transporter activity Cydrannau o'r gell • integral component of membrane • Cellbilen • basolateral plasma membrane • bilen • extracellular exosome • integral component of plasma membrane • vacuolar membrane Prosesau biolegol • cobalamin metabolic process • leukotriene metabolic process • transmembrane transport • cobalamin transport • vitamin transmembrane transport • xenobiotic transmembrane transport • glutathione transmembrane transport • xenobiotic transport • GO:0015915 transport • phospholipid translocation • cell chemotaxis • sphingolipid translocation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4363	n/a
Ensembl	ENSG00000278183 ENSG00000103222	n/a
UniProt	P33527	n/a
RefSeq (mRNA)	NM_004996 NM_019862 NM_019898 NM_019899 NM_019900 NM_019901 NM_019902	n/a
RefSeq (protein)	NP_004987	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ABCC1 yw ABCC1 a elwir hefyd yn ATP binding cassette subfamily C member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ABCC1.

• MRP
• ABCC
• GS-X
• MRP1
• ABC29

Llyfryddiaeth

• "Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter. ". Lab Invest. 2017. PMID 28414325.
• "Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation. ". Biochem Biophys Res Commun. 2017. PMID 27908733.
• "ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy. ". Sci Transl Med. 2016. PMID 27535620.
• "Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. ". Mol Pharmacol. 2016. PMID 27297967.
• "Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells.". Biochem Biophys Res Commun. 2016. PMID 27038543.