MAPK1

MAPK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I
Dynodwyr
Cyfenwau	MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1, NS13
Dynodwyr allanol	OMIM: 176948 HomoloGene: 37670 GeneCards: MAPK1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phosphatase binding; • ATP binding; • protein kinase activity; • transcription factor binding; • transferase activity; • mitogen-activated protein kinase kinase kinase binding; • phosphotyrosine residue binding; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • DNA binding; • nucleotide binding; • RNA polymerase II CTD heptapeptide repeat kinase activity; • protein serine/threonine kinase activity; • kinase activity; • identical protein binding; • MAP kinase activity; • double-stranded DNA binding; • MAP kinase kinase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • focal adhesion; • microtubule organizing center; • mitocondria; • caveola; • dendrite cytoplasm; • Cytosgerbwd; • cnewyllyn cell; • extracellular exosome; • perikaryon; • late endosome; • Golgi apparatus; • spindle; • axon; • early endosome; • mitotic spindle; • pseudopodium; • extracellular region; • nucleoplasm; • azurophil granule lumen; • ficolin-1-rich granule lumen; • Cellbilen; • GO:0097483, GO:0097481 postsynaptic density; • bilen; • GO:0009327 protein-containing complex;
Prosesau biolegol	• caveolin-mediated endocytosis; • positive regulation of telomere capping; • response to exogenous dsRNA; • cardiac neural crest cell development involved in heart development; • positive regulation of translation; • cellular response to DNA damage stimulus; • platelet activation; • Fc-epsilon receptor signaling pathway; • protein phosphorylation; • face development; • cellular response to granulocyte macrophage colony-stimulating factor stimulus; • regulation of DNA-binding transcription factor activity; • animal organ morphogenesis; • cell cycle; • ERBB signaling pathway; • GO:0097285 apoptotic process; • B cell receptor signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • Fc-gamma receptor signaling pathway involved in phagocytosis; • thymus development; • negative regulation of cell differentiation; • ERK1 and ERK2 cascade; • labyrinthine layer blood vessel development; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • GO:0022415 viral process; • response to toxic substance; • regulation of stress-activated MAPK cascade; • chemical synaptic transmission; • growth hormone receptor signaling pathway via JAK-STAT; • cytosine metabolic process; • phosphorylation; • outer ear morphogenesis; • response to estrogen; • chemotaxis; • response to lipopolysaccharide; • thyroid gland development; • response to epidermal growth factor; • positive regulation of telomerase activity; • sensory perception of pain; • peptidyl-threonine phosphorylation; • trachea formation; • lipopolysaccharide-mediated signaling pathway; • mammary gland epithelial cell proliferation; • GO:0007243 intracellular signal transduction; • lung morphogenesis; • neural crest cell development; • positive regulation of cell migration; • regulation of early endosome to late endosome transport; • response to stress; • positive regulation of telomere maintenance via telomerase; • MAPK cascade; • axon guidance; • fibroblast growth factor receptor signaling pathway; • positive regulation of peptidyl-threonine phosphorylation; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of cell population proliferation; • regulation of cellular response to heat; • Bergmann glial cell differentiation; • regulation of Golgi inheritance; • T cell receptor signaling pathway; • regulation of cytoskeleton organization; • GO:0072468 signal transduction; • long-term potentiation; • regulation of ossification; • regulation of phosphatidylinositol 3-kinase signaling; • neutrophil degranulation; • regulation of gene expression; • cellular response to organic substance; • GO:0010260 heneiddio; • learning or memory; • GO:1901313 positive regulation of gene expression; • diadenosine tetraphosphate biosynthetic process; • regulation of cellular pH; • cellular response to amino acid starvation; • GO:0072353 cellular response to reactive oxygen species; • response to nicotine; • decidualization; • stress-activated MAPK cascade; • positive regulation of cardiac muscle cell proliferation; • cellular response to cadmium ion; • cellular response to tumor necrosis factor; • cellular response to dopamine; • positive regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologau
	5594
	n/a
	ENSG00000100030
	n/a
	P28482
	n/a
	NM_138957; NM_002745
	n/a
	NP_002736; NP_620407
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK1 yw MAPK1 a elwir hefyd yn Mitogen-activated protein kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q11.22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK1.

ERK
p38
p40
p41
ERK2
ERT1
ERK-2
MAPK2
PRKM1
PRKM2
P42MAPK
p41mapk
p42-MAPK

Llyfryddiaeth

"Iodine Promotes Tumorigenesis of Thyroid Cancer by Suppressing Mir-422a and Up-Regulating MAPK1. ". Cell Physiol Biochem. 2017. PMID 28992617.
"Central amygdala activation of extracellular signal-regulated kinase 1 and age-dependent changes in inflammatory pain sensitivity in mice. ". Neurobiol Aging. 2017. PMID 28526294.
"MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer. ". Oncol Rep. 2017. PMID 28393232.
"Neferine Enhances the Antitumor Effect of Mitomycin-C in Hela Cells Through the Activation of p38-MAPK Pathway. ". J Cell Biochem. 2017. PMID 28328092.
"Human Th17 Migration in Three-Dimensional Collagen Involves p38 MAPK.". J Cell Biochem. 2017. PMID 28198034.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAPK1 - Cronfa NCBI

[1]

[2]