EP300 Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1L3E , 1P4Q , 2K8F , 2MH0 , 2MZD , 3BIY , 3I3J , 3IO2 , 3P57 , 3T92 , 4BHW , 4PZR , 4PZS , 4PZT , 5BT3
Dynodwyr Cyfenwau EP300 Dynodwyr allanol OMIM: 602700 HomoloGene: 1094 GeneCards: EP300 Ontoleg y genyn Gweithrediad moleciwlaidd • protein C-terminus binding • transcription factor binding • GO:0001104 transcription coregulator activity • metal ion binding • acyltransferase activity • transferase activity • beta-catenin binding • pre-mRNA intronic binding • zinc ion binding • chromatin binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • acetyltransferase activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • p53 binding • androgen receptor binding • chromatin DNA binding • histone acetyltransferase activity • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor • peptide N-acetyltransferase activity • peptide-lysine-N-acetyltransferase activity • protein propionyltransferase activity • STAT family protein binding • peptide butyryltransferase activity • histone crotonyltransferase activity • histone butyryltransferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • histone acetyltransferase complex • transcription regulator complex • nucleoplasm • cytoplasm • cytosol • Cromosom Prosesau biolegol • somitogenesis • proses rythmig • transcription by RNA polymerase II • histone H2B acetylation • animal organ morphogenesis • cell cycle • B cell differentiation • GO:0097285 apoptotic process • GO:0009373 regulation of transcription, DNA-templated • lung development • N-terminal peptidyl-lysine acetylation • platelet formation • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • regulation of transcription from RNA polymerase II promoter in response to hypoxia • GO:0022415 viral process • protein acetylation • Notch signaling pathway • cellular response to UV • protein stabilization • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • nervous system development • regulation of autophagy • regulation of androgen receptor signaling pathway • positive regulation of protein binding • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • fat cell differentiation • positive regulation by host of viral transcription • megakaryocyte development • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • internal protein amino acid acetylation • regulation of cell cycle • regulation of tubulin deacetylation • GO:1901313 positive regulation of gene expression • histone H4 acetylation • regulation of cellular response to heat • transcription-coupled nucleotide-excision repair • skeletal muscle tissue development • positive regulation of type I interferon production • response to estrogen • response to hypoxia • regulation of signal transduction by p53 class mediator • internal peptidyl-lysine acetylation • beta-catenin-TCF complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • macrophage derived foam cell differentiation • Rhythm circadaidd • protein deubiquitination • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein destabilization • regulation of megakaryocyte differentiation • histone acetylation • epigenetic maintenance of chromatin in transcription-competent conformation • peptidyl-lysine propionylation • peptidyl-lysine crotonylation • peptidyl-lysine butyrylation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn EP300 yw EP300 a elwir hefyd yn E1A binding protein p300 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.2.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EP300.
"A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease. ". Neurotox Res . 2016. PMID 27256286 . "From Whole Gene Deletion to Point Mutations of EP300-Positive Rubinstein-Taybi Patients: New Insights into the Mutational Spectrum and Peculiar Clinical Hallmarks. ". Hum Mutat . 2016. PMID 26486927 . "Molecular Basis for the Regulation of Transcriptional Coactivator p300 in Myogenic Differentiation. ". Sci Rep . 2015. PMID 26354606 . "Expanding the phenotypic spectrum in EP300-related Rubinstein-Taybi syndrome. ". Am J Med Genet A . 2015. PMID 25712426 . "The PHD finger of p300 influences its ability to acetylate histone and non-histone targets. ". J Mol Biol . 2014. PMID 25158095 . 
