YBX3 Dynodwyr Cyfenwau YBX3 , CSDA, CSDA1, DBPA, ZONAB, Y-box binding protein 3Dynodwyr allanol OMIM: 603437 HomoloGene: 2708 GeneCards: YBX3 Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • mRNA 3'-UTR binding • single-stranded DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • double-stranded DNA binding • RNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • polysome binding Cydrannau o'r gell • polysome • bicellular tight junction • perinuclear region of cytoplasm • cnewyllyn cell • cytoplasm • cytosol Prosesau biolegol • male gonad development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • negative regulation of necroptotic process • positive regulation of cytoplasmic translation • cellular response to tumor necrosis factor • positive regulation of organ growth • negative regulation of apoptotic process • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • cellular hyperosmotic response • negative regulation of skeletal muscle tissue development • spermatogenesis • response to cold • fertilization • 3'-UTR-mediated mRNA stabilization Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn YBX3 yw YBX3 a elwir hefyd yn Y-box binding protein 3 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YBX3.
"DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue. ". Int J Oncol . 2012. PMID 22159460 .
"Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells. ". Acta Pharmacol Sin . 2009. PMID 19749785 .
"Gene expression profile analysis of dbpA knockdown in colorectal cancer cells. ". Cell Biol Int . 2016. PMID 27569444 .
"RNAi-mediated downregulation of DNA binding protein A inhibits tumorigenesis in colorectal cancer. ". Int J Mol Med . 2016. PMID 27430286 .
"Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical reassessment of YBX3/ZONAB/CSDA expression. ". BMC Mol Biol . 2014. PMID 24885929 .