VPS4A

VPS4A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YXR, 2JQ9, 2K3W
Dynodwyr
Cyfenwau	VPS4A, SKD1, SKD1A, SKD2, VPS4, VPS4-1, vacuolar protein sorting 4 homolog A, CIMDAG
Dynodwyr allanol	OMIM: 609982 HomoloGene: 69132 GeneCards: VPS4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein domain specific binding • microtubule-severing ATPase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • ATP binding • ATPase activity • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • ESCRT III complex • cytosol • endosome • late endosome • centrosome • spindle pole • vacuolar membrane • late endosome membrane • Flemming body • bilen • Cellbilen • midbody • early endosome • perinuclear region of cytoplasm • lysosome • extracellular exosome • cnewyllyn cell • endosome membrane Prosesau biolegol • late endosomal microautophagy • endosomal vesicle fusion • viral release from host cell • abscission • viral budding via host ESCRT complex • nucleus organization • GO:0019067 viral life cycle • multivesicular body assembly • vacuole organization • vesicle uncoating • regulation of protein localization • Cellraniad • intracellular cholesterol transport • ESCRT complex disassembly • vesicle budding from membrane • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway • GO:0015915 transport • protein transport • positive regulation of viral life cycle • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • cell cycle • negative regulation of cytokinesis • septum digestion after cytokinesis • mitotic metaphase plate congression • positive regulation of exosomal secretion • vesicle-mediated transport • regulation of protein localization to plasma membrane • ESCRT III complex disassembly • cytoplasmic microtubule organization • endosomal transport • macroautophagy • positive regulation of viral budding via host ESCRT complex • actomyosin contractile ring contraction • protein targeting to lysosome • nuclear envelope organization • nuclear membrane reassembly • mitotic cytokinesis checkpoint signaling • cytoskeleton-dependent cytokinesis • midbody abscission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	27183	n/a
Ensembl	ENSG00000132612	n/a
UniProt	Q9UN37	n/a
RefSeq (mRNA)	NM_013245	n/a
RefSeq (protein)	NP_037377 NP_037377.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VPS4A yw VPS4A a elwir hefyd yn Vacuolar protein sorting 4A (Yeast), isoform CRA_c a Vacuolar protein sorting 4 homolog a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VPS4A.

• SKD1
• SKD2
• VPS4
• SKD1A
• VPS4-1

Llyfryddiaeth

• "The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III. ". Traffic. 2013. PMID 23009658.
• "The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. ". PLoS One. 2011. PMID 22216284.
• "Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis. ". Nat Cell Biol. 2017. PMID 28604678.
• "Mammalian farnesyltransferase α subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)--dependent intracellular trafficking through recycling endosomes. ". Biochem Biophys Res Commun. 2015. PMID 26551458.
• "Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells.". Hepatology. 2015. PMID 25503676.