VAMP2

VAMP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3FIE, 3FII, 3RK2, 3RK3, 3RL0
Dynodwyr
Cyfenwau	VAMP2, SYB2, VAMP-2, vesicle associated membrane protein 2, NEDHAHM
Dynodwyr allanol	OMIM: 185881 HomoloGene: 7591 GeneCards: VAMP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SNAP receptor activity • protein self-association • GO:0001948, GO:0016582 protein binding • syntaxin-1 binding • SNARE binding • calmodulin binding • syntaxin binding • phospholipid binding • calcium-dependent protein binding Cydrannau o'r gell • integral component of membrane • cytosol • clathrin-sculpted monoamine transport vesicle membrane • bilen • secretory granule membrane • Cellbilen • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • synapse • integral component of plasma membrane • synaptic vesicle membrane • zymogen granule membrane • cell junction • neuron projection • GO:0016023 cytoplasmic vesicle • clathrin-coated vesicle • clathrin-sculpted glutamate transport vesicle membrane • secretory granule • intracellular membrane-bounded organelle • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex • synaptobrevin 2-SNAP-25-syntaxin-1a complex • SNARE complex • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex • voltage-gated potassium channel complex • trans-Golgi network • synaptic vesicle • fesigl • perinuclear region of cytoplasm • neuron projection terminus • clathrin-coated vesicle membrane Prosesau biolegol • natural killer cell degranulation • mucus secretion • regulation of histamine secretion by mast cell • neutrophil degranulation • glutamate secretion • vesicle fusion • eosinophil degranulation • vesicle-mediated transport • exocytosis • response to glucose • membrane fusion • regulation of delayed rectifier potassium channel activity • calcium-ion regulated exocytosis • regulation of exocytosis • positive regulation of intracellular protein transport • protein transport • Golgi to plasma membrane protein transport • synaptic vesicle exocytosis • cellular response to insulin stimulus • long-term potentiation • regulation of vesicle-mediated transport • membrane organization • GO:0034622 protein-containing complex assembly • post-Golgi vesicle-mediated transport • GO:0010554 neurotransmitter secretion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6844	n/a
Ensembl	ENSG00000220205	n/a
UniProt	P63027	n/a
RefSeq (mRNA)	NM_014232 NM_001330125	n/a
RefSeq (protein)	NP_001317054 NP_055047	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAMP2 yw VAMP2 a elwir hefyd yn Vesicle associated membrane protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VAMP2.

• SYB2
• VAMP-2

Llyfryddiaeth

• "Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5. ". FEBS Lett. 2012. PMID 22172278.
• "Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F. ". Nat Struct Mol Biol. 2009. PMID 19543288.
• "An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of Expression in Hematolymphoid Neoplasia. ". Am J Clin Pathol. 2016. PMID 27247366.
• "Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5. ". Sci Rep. 2016. PMID 26794648.
• "Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells.". Cell Microbiol. 2016. PMID 26617273.