UBE2L3

UBE2L3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1C4Z, 1FBV, 3SQV, 3SY2, 4Q5E, 4Q5H, 5HPT
Dynodwyr
Cyfenwau	UBE2L3, E2-F1, L-UBC, UBCH7, UbcM4, ubiquitin conjugating enzyme E2 L3
Dynodwyr allanol	OMIM: 603721 HomoloGene: 43226 GeneCards: UBE2L3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • GO:0001105 transcription coactivator activity • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • ubiquitin-protein transferase activator activity • enzyme binding • ATP binding • ubiquitin protein ligase binding • RNA binding • ubiquitin conjugating enzyme activity Cydrannau o'r gell • cytoplasm • ubiquitin ligase complex • extracellular exosome • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • cell cycle phase transition • cellular response to steroid hormone stimulus • GO:0009373 regulation of transcription, DNA-templated • ubiquitin-dependent protein catabolic process • positive regulation of protein targeting to mitochondrion • protein polyubiquitination • transcription, DNA-templated • protein K11-linked ubiquitination • cellular response to glucocorticoid stimulus • positive regulation of ubiquitin-protein transferase activity • cell population proliferation • positive regulation of protein ubiquitination • protein ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7332	n/a
Ensembl	ENSG00000185651	n/a
UniProt	P68036	n/a
RefSeq (mRNA)	NM_001256355 NM_001256356 NM_003347 NM_198157	n/a
RefSeq (protein)	NP_001243284 NP_001243285 NP_003338 NP_003338.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2L3 yw UBE2L3 a elwir hefyd yn Ubiquitin-conjugating enzyme E2L 3, isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2L3.

• E2-F1
• L-UBC
• UBCH7
• UbcM4

Llyfryddiaeth

• "Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. ". Proc Natl Acad Sci U S A. 2012. PMID 22308380.
• "Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population. ". Ann Rheum Dis. 2012. PMID 22294623.
• "The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population. ". BMC Endocr Disord. 2016. PMID 27094594.
• "UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. ". Am J Hum Genet. 2015. PMID 25640675.
• "A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.". Genes Immun. 2012. PMID 22476155.