TSG101

TSG101
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KPP, 1KPQ, 1M4P, 1M4Q, 1S1Q, 2F0R, 3IV1, 3OBQ, 3OBS, 3OBU, 3OBX, 3P9G, 3P9H, 4EJE, 4YC1, 4ZNY
Dynodwyr
Cyfenwau	TSG101, TSG10, VPS23, tumor susceptibility 101
Dynodwyr allanol	OMIM: 601387 HomoloGene: 4584 GeneCards: TSG101
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein homodimerization activity • GO:0001106 transcription corepressor activity • calcium-dependent protein binding • ubiquitin binding • GO:0001948, GO:0016582 protein binding • nuclear receptor coactivator activity • virion binding • ubiquitin protein ligase binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • multivesicular body • endosome • late endosome • bilen • late endosome membrane • Cellbilen • early endosome • nucleolus • endosome membrane • extracellular exosome • ESCRT I complex • cnewyllyn cell • cytosol • host cell • microtubule organizing center • Cytosgerbwd • early endosome membrane • Flemming body Prosesau biolegol • GO:0046795 intracellular transport of virus • cell differentiation • positive regulation of ubiquitin-dependent endocytosis • regulation of extracellular exosome assembly • viral budding via host ESCRT complex • GO:0019067 viral life cycle • endosome to lysosome transport • multivesicular body assembly • protein monoubiquitination • viral budding • keratinocyte differentiation • Cellraniad • endosomal transport • GO:0000046 autophagosome maturation • regulation of cell growth • protein transport • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • regulation of MAP kinase activity • positive regulation of exosomal secretion • cell cycle • regulation of growth • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cell population proliferation • GO:0022415 viral process • exosomal secretion • macroautophagy • negative regulation of epidermal growth factor receptor signaling pathway • negative regulation of epidermal growth factor-activated receptor activity • GO:0015915 transport • extracellular transport • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7251	n/a
Ensembl	ENSG00000074319	n/a
UniProt	Q99816	n/a
RefSeq (mRNA)	NM_006292	n/a
RefSeq (protein)	NP_006283	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TSG101 yw TSG101 a elwir hefyd yn Tumor susceptibility gene 101 protein a Tumor susceptibility 101 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TSG101.

• TSG10
• VPS23

Llyfryddiaeth

• "Interaction with Tsg101 is necessary for the efficient transport and release of nucleocapsids in marburg virus-infected cells. ". PLoS Pathog. 2014. PMID 25330247.
• "Human papillomavirus infection requires the TSG101 component of the ESCRT machinery. ". Virology. 2014. PMID 25010273.
• "TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death. ". Med Sci Monit. 2015. PMID 26537625.
• "Gene and protein expression in the oxaliplatin-resistant HT29/L-OHP human colon cancer cell line. ". Genet Mol Res. 2015. PMID 26400331.
• "Functional Interaction Between the ESCRT-I Component TSG101 and the HSV-1 Tegument Ubiquitin Specific Protease.". J Cell Physiol. 2015. PMID 25510868.