TRIM5

TRIM5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ECV, 2YRG
Dynodwyr
Cyfenwau	TRIM5, RNF88, TRIM5alpha, tripartite motif containing 5
Dynodwyr allanol	OMIM: 608487 HomoloGene: 75345 GeneCards: TRIM5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • protein homodimerization activity • GO:0008329 pattern recognition receptor activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein kinase binding • transferase activity • GO:0050372 ubiquitin-protein transferase activity Cydrannau o'r gell • cytoplasm • cytosol • omegasome • intracellular anatomical structure • cnewyllyn cell • P-body Prosesau biolegol • regulation of lipopolysaccharide-mediated signaling pathway • interferon-gamma-mediated signaling pathway • protein K63-linked ubiquitination • immune system process • protein trimerization • positive regulation of DNA-binding transcription factor activity • regulation of protein localization • autophagy • positive regulation of NF-kappaB transcription factor activity • defense response to virus • protein ubiquitination • activation of innate immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • GO:0022415 viral process • positive regulation of MAPK cascade • pattern recognition receptor signaling pathway • negative regulation of viral entry into host cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	85363	n/a
Ensembl	ENSG00000132256	n/a
UniProt	Q9C035	n/a
RefSeq (mRNA)	NM_033034 NM_033092 NM_033093	n/a
RefSeq (protein)	NP_149023 NP_149083 NP_149084	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRIM5 yw TRIM5 a elwir hefyd yn Tripartite motif containing 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.4.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRIM5.

• RNF88
• TRIM5alpha

Llyfryddiaeth

• "Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ". Retrovirology. 2017. PMID 28420387.
• "Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets. ". Nature. 2016. PMID 27919079.
• "TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil. ". Immunol Res. 2016. PMID 27388872.
• "TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction. ". J Virol. 2016. PMID 26764007.
• "TRIM5α H43Y Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis.". AIDS Res Hum Retroviruses. 2015. PMID 26398573.