TOPBP1

TOPBP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WF6, 2XNH, 2XNK, 3AL2, 3AL3, 3JVE, 3OLC, 3PD7, 3UEN, 3UEO
Dynodwyr
Cyfenwau	TOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1, DNA topoisomerase II binding protein 1, Dpb11
Dynodwyr allanol	OMIM: 607760 HomoloGene: 38262 GeneCards: TOPBP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • isomerase activity Cydrannau o'r gell • PML body • spindle pole • male germ cell nucleus • nucleoplasm • microtubule organizing center • Cromosom • condensed nuclear chromosome • actin cytoskeleton • Cytosgerbwd • cnewyllyn cell • cytoplasm • nuclear body Prosesau biolegol • response to ionizing radiation • DNA metabolic process • cellular response to DNA damage stimulus • GO:0100026 DNA repair • DNA replication initiation • mitotic G2 DNA damage checkpoint signaling • mitotic DNA replication checkpoint signaling • DNA replication • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11073	n/a
Ensembl	ENSG00000163781	n/a
UniProt	Q92547	n/a
RefSeq (mRNA)	NM_007027 NM_001363889	n/a
RefSeq (protein)	NP_008958 NP_001350818 NP_008958.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TOPBP1 yw TOPBP1 a elwir hefyd yn Topoisomerase (DNA) II binding protein 1 a DNA topoisomerase II binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TOPBP1.

• TOP2BP1

Llyfryddiaeth

• "Topoisomerase IIβ binding protein 1 c.*229C>T (rs115160714) gene polymorphism and endometrial cancer risk. ". Pathol Oncol Res. 2014. PMID 24346708.
• "[Molecular basis of gynecological oncology - TopBP1 protein as the guardian of genome integrity]. ". Ginekol Pol. 2013. PMID 23819404.
• "The c.*229C > T gene polymorphism in 3'UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma. ". Tumour Biol. 2016. PMID 26503213.
• "TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells. ". J Cell Biol. 2015. PMID 26283799.
• "Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension.". Am J Respir Crit Care Med. 2014. PMID 24702692.