TCF7L2

TCF7L2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GL7, 1JDH, 1JPW
Dynodwyr
Cyfenwau	TCF7L2, TCF-4, TCF4, transcription factor 7 like 2
Dynodwyr allanol	OMIM: 602228 HomoloGene: 7564 GeneCards: TCF7L2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • beta-catenin binding • gamma-catenin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • armadillo repeat domain binding • protein kinase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding Cydrannau o'r gell • beta-catenin-TCF7L2 complex • PML body • nucleoplasm • protein-DNA complex • cnewyllyn cell • transcription regulator complex Prosesau biolegol • positive regulation of heparan sulfate proteoglycan biosynthetic process • positive regulation of protein kinase B signaling • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • response to glucose • Wnt signaling pathway • regulation of smooth muscle cell proliferation • negative regulation of DNA-binding transcription factor activity • canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition • transcription, DNA-templated • positive regulation of protein export from nucleus • maintenance of DNA repeat elements • blood vessel development • myoblast fate commitment • canonical Wnt signaling pathway • pancreas development • positive regulation of protein binding • regulation of hormone metabolic process • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • beta-catenin-TCF complex assembly • Wnt signaling pathway, calcium modulating pathway • positive regulation of insulin secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of type B pancreatic cell apoptotic process • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of epithelial cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6934	n/a
Ensembl	ENSG00000148737	n/a
UniProt	Q9NQB0	n/a
RefSeq (mRNA)	NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286 NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756 NM_001349870 NM_001349871 NM_001363501 NM_001367943	n/a
RefSeq (protein)	NP_001139746 NP_001139755 NP_001139756 NP_001139757 NP_001139758 NP_001185454 NP_001185455 NP_001185456 NP_001185457 NP_001185458 NP_001185459 NP_001185460 NP_110383 NP_001336799 NP_001336800 NP_001350430 NP_001354872 NP_001139757.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TCF7L2 yw TCF7L2 a elwir hefyd yn TCF7L2 isoform pFC8A_TCF7L2_ex1-11-13-14 , T-cell factor-4 variant L a Transcription factor 7 like 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.2-q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TCF7L2.

• TCF4
• TCF-4

Llyfryddiaeth

• "Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol. ". PLoS One. 2017. PMID 29182660.
• "Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma. ". Cell Mol Biol Lett. 2016. PMID 28536608.
• "Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. ". J Health Popul Nutr. 2017. PMID 28420445.
• "A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women. ". PLoS One. 2017. PMID 28253288.
• "Glucose tolerance and free fatty acid metabolism in adults with variations in TCF7L2 rs7903146.". Metabolism. 2017. PMID 28183453.