SOS1

SOS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2II0
Dynodwyr
Cyfenwau	SOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-1
Dynodwyr allanol	OMIM: 182530 HomoloGene: 4117 GeneCards: SOS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • guanyl-nucleotide exchange factor activity • SH3 domain binding Cydrannau o'r gell • cytosol • GO:0097483, GO:0097481 postsynaptic density • Cellbilen • neuronal cell body • cytoplasm • nucleosome Prosesau biolegol • regulation of pro-B cell differentiation • hair follicle development • GO:1901047 insulin receptor signaling pathway • roof of mouth development • heart trabecula morphogenesis • regulation of T cell proliferation • positive regulation of small GTPase mediated signal transduction • blood vessel morphogenesis • epidermal growth factor receptor signaling pathway • vitellogenesis • multicellular organism growth • lymphocyte homeostasis • heart morphogenesis • B cell homeostasis • eyelid development in camera-type eye • MAPK cascade • axon guidance • Fc-epsilon receptor signaling pathway • regulation of T cell differentiation in thymus • pericardium morphogenesis • positive regulation of apoptotic process • midbrain morphogenesis • cardiac atrium morphogenesis • Ras protein signal transduction • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of epidermal growth factor receptor signaling pathway • leukocyte migration • GO:0072468 signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • small GTPase mediated signal transduction • ERBB2 signaling pathway • G protein-coupled receptor signaling pathway • cytokine-mediated signaling pathway • neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6654	n/a
Ensembl	ENSG00000115904	n/a
UniProt	Q07889	n/a
RefSeq (mRNA)	NM_005633 NM_001382394 NM_001382395	n/a
RefSeq (protein)	NP_005624 NP_001369323 NP_001369324	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOS1 yw SOS1 a elwir hefyd yn SOS Ras/Rac guanine nucleotide exchange factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOS1.

• GF1
• HGF
• NS4
• GGF1
• GINGF
• SOS-1

Llyfryddiaeth

• "One-way membrane trafficking of SOS in receptor-triggered Ras activation. ". Nat Struct Mol Biol. 2016. PMID 27501536.
• "Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes. ". PLoS Genet. 2016. PMID 27304678.
• "SOS1 frameshift mutations cause pure mucosal neuroma syndrome, a clinical phenotype distinct from multiple endocrine neoplasia type 2B. ". Clin Endocrinol (Oxf). 2016. PMID 26708403.
• "Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. ". J Biol Chem. 2015. PMID 25825487.
• "Differential allelic expression of SOS1 and hyperexpression of the activating SOS1 c.755C variant in a Noonan syndrome family.". Eur J Hum Genet. 2015. PMID 25712082.