SOCS2

SOCS2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C9W, 4JGH, 5BO4
Dynodwyr
Cyfenwau	SOCS2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2
Dynodwyr allanol	OMIM: 605117 HomoloGene: 2880 GeneCards: SOCS2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin-like growth factor receptor binding • protein kinase inhibitor activity • JAK pathway signal transduction adaptor activity • GO:0001948, GO:0016582 protein binding • growth hormone receptor binding • 1-phosphatidylinositol-3-kinase regulator activity Cydrannau o'r gell • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex Prosesau biolegol • receptor signaling pathway via JAK-STAT • response to estradiol • GO:0007243 intracellular signal transduction • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • negative regulation of apoptotic process • GO:1903105 negative regulation of insulin receptor signaling pathway • cellular response to hormone stimulus • growth hormone receptor signaling pathway • regulation of signal transduction • regulation of cell growth • protein ubiquitination • regulation of growth • negative regulation of signal transduction • negative regulation of receptor signaling pathway via JAK-STAT • positive regulation of signal transduction • lactation • regulation of multicellular organism growth • negative regulation of multicellular organism growth • post-translational protein modification • positive regulation of neuron differentiation • mammary gland alveolus development • interleukin-7-mediated signaling pathway • regulation of phosphatidylinositol 3-kinase activity • phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8835	n/a
Ensembl	ENSG00000120833	n/a
UniProt	O14508	n/a
RefSeq (mRNA)	NM_001270467 NM_001270468 NM_001270469 NM_001270470 NM_001270471 NM_003877	n/a
RefSeq (protein)	NP_001257396 NP_001257397 NP_001257398 NP_001257399 NP_001257400 NP_003868	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOCS2 yw SOCS2 a elwir hefyd yn Suppressor of cytokine signaling 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOCS2.

• CIS2
• SSI2
• Cish2
• SSI-2
• SOCS-2
• STATI2

Llyfryddiaeth

• "Suppressor of Cytokine Signaling-2 (SOCS2) Regulates the Microglial Response and Improves Functional Outcome after Traumatic Brain Injury in Mice. ". PLoS One. 2016. PMID 27071013.
• "SOCS2: physiological and pathological functions. ". Front Biosci (Elite Ed). 2016. PMID 26709655.
• "A herpes simplex virus type 2-encoded microRNA promotes tumor cell metastasis by targeting suppressor of cytokine signaling 2 in lung cancer. ". Tumour Biol. 2017. PMID 28468588.
• "GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2. ". Mol Cell Endocrinol. 2017. PMID 27566229.
• "The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma.". Tumour Biol. 2016. PMID 27465557.