SLC9A1

SLC9A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Y4E, 2BEC, 2E30, 2KBV, 2L0E, 2MDF, 2YGG
Dynodwyr
Cyfenwau	SLC9A1, APNH, NHE-1, NHE1, PPP1R143, LIKNS, Sodium–hydrogen antiporter 1, solute carrier family 9 member A1
Dynodwyr allanol	OMIM: 107310 HomoloGene: 20660 GeneCards: SLC9A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • calcium-dependent protein binding • phosphatidylinositol-4,5-bisphosphate binding • antiporter activity • solute:proton antiporter activity • sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential • calmodulin binding • GO:0001948, GO:0016582 protein binding • GO:0032947 molecular adaptor activity • protein phosphatase 2B binding • sodium:proton antiporter activity • potassium:proton antiporter activity Cydrannau o'r gell • cytoplasm • bilen • focal adhesion • T-tubule • mitocondria • perinuclear region of cytoplasm • cation-transporting ATPase complex • cell surface • apical plasma membrane • Reticwlwm endoplasmig • membrane raft • extracellular exosome • lamellipodium • integral component of membrane • intercalated disc • Cellbilen • nucleoplasm • endoplasmic reticulum membrane • integral component of plasma membrane • basolateral plasma membrane • sarcolemma Prosesau biolegol • regulation of cardiac muscle contraction by calcium ion signaling • regulation of sensory perception of pain • positive regulation of the force of heart contraction • positive regulation of cardiac muscle hypertrophy • cellular response to epinephrine stimulus • positive regulation of action potential • cellular response to mechanical stimulus • maintenance of cell polarity • cellular response to hypoxia • positive regulation of mitochondrial membrane permeability • response to muscle stretch • proton transmembrane transport • cellular sodium ion homeostasis • cardiac muscle cell differentiation • cludo ïon • positive regulation of cell growth • cellular response to insulin stimulus • regulation of focal adhesion assembly • regulation of cardiac muscle cell membrane potential • response to acidic pH • cell differentiation • regulation of the force of heart contraction • GO:1904579 cellular response to organic cyclic compound • cellular response to acidic pH • cation transport • negative regulation of apoptotic process • regulation of the force of heart contraction by cardiac conduction • regulation of pH • cardiac muscle cell contraction • neuron death • hyaluronan catabolic process • GO:1904578 response to organic cyclic compound • sodium ion transport • regulation of intracellular pH • GO:0010740 positive regulation of intracellular signal transduction • regulation of stress fiber assembly • positive regulation of calcineurin-NFAT signaling cascade • protein complex oligomerization • sodium ion import across plasma membrane • positive regulation of apoptotic process • GO:1904577 cellular response to antibiotic • positive regulation of calcium:sodium antiporter activity • cell migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to electrical stimulus • potassium ion transmembrane transport • transmembrane transport • GO:0015915 transport • cellular response to cold • sodium ion export across plasma membrane • anion transmembrane transport • sodium ion transmembrane transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6548	n/a
Ensembl	ENSG00000090020	n/a
UniProt	P19634	n/a
RefSeq (mRNA)	NM_003047	n/a
RefSeq (protein)	NP_003038	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLC9A1 yw SLC9A1 a elwir hefyd yn Sodium/hydrogen exchanger 1 a Solute carrier family 9 member A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLC9A1.

• APNH
• NHE1
• LIKNS
• NHE-1
• PPP1R143

Llyfryddiaeth

• "Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na+/H+ Exchanger Function. ". PLoS One. 2016. PMID 27636896.
• "Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1. ". Carcinogenesis. 2016. PMID 27287871.
• "Elevated Na+/H+ exchanger-1 expression enhances the metastatic collective migration of head and neck squamous cell carcinoma cells. ". Biochem Biophys Res Commun. 2017. PMID 28268168.
• "NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion. ". Oncol Rep. 2017. PMID 28098891.
• "A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.". J Biol Chem. 2016. PMID 27650500.