SLC6A3

SLC6A3
Dynodwyr
Cyfenwau	SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
Dynodwyr allanol	OMIM: 126455 HomoloGene: 55547 GeneCards: SLC6A3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein N-terminus binding; • dopamine:sodium symporter activity; • metal ion binding; • neurotransmitter:sodium symporter activity; • dopamine binding; • GO:0001948, GO:0016582 protein binding; • symporter activity; • monoamine transmembrane transporter activity; • GO:0032403 protein-containing complex binding; • protease binding; • signaling receptor binding; • protein phosphatase 2A binding;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • Cellbilen; • integral component of plasma membrane; • cell surface; • axon; • flotillin complex; • neuronal cell body; • membrane raft; • presynapse; • neuron projection; • dopaminergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Prosesau biolegol	• adwaith i gocên; • prepulse inhibition; • GO:1904578 response to organic cyclic compound; • locomotory behavior; • dopamine biosynthetic process; • response to nicotine; • GO:0010260 heneiddio; • neurotransmitter biosynthetic process; • monoamine transport; • adenohypophysis development; • regulation of dopamine metabolic process; • response to iron ion; • sensory perception of smell; • dopamine uptake involved in synaptic transmission; • dopamine catabolic process; • dopamine transport; • positive regulation of multicellular organism growth; • response to cAMP; • lactation; • response to ethanol; • neurotransmitter transport; • dopamine uptake; • transmembrane transport; • neurotransmitter uptake;
	Sources:Amigo / QuickGO
Orthologau
	6531
	n/a
	ENSG00000142319; ENSG00000276996
	n/a
	Q01959
	n/a
	NM_001044
	n/a
	NP_001035
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SLC6A3 yw SLC6A3 a elwir hefyd yn Solute carrier family 6 member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p15.33.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SLC6A3.

DAT
DAT1
PKDYS

Llyfryddiaeth[golygu | golygu cod]

SLC6A3-Related Dopamine Transporter Deficiency Syndrome. 1993. PMID 28749637.
"Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization. ". J Biol Chem. 2017. PMID 28584050.
"A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking. ". AIDS Care. 2017. PMID 28278565.
"The SLC6A3 gene possibly affects susceptibility to late-onset alcohol dependence but not specific personality traits in a Han Chinese population. ". PLoS One. 2017. PMID 28182634.
"Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension.". DNA Cell Biol. 2017. PMID 28055236.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] SLC6A3 - Cronfa NCBI

[1]

[2]