RFX1

RFX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DP7
Dynodwyr
Cyfenwau	RFX1, EFC, RFX, regulatory factor X1
Dynodwyr allanol	OMIM: 600006 HomoloGene: 2189 GeneCards: RFX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cydrannau o'r gell • intracellular membrane-bounded organelle • nucleoplasm • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5989	n/a
Ensembl	ENSG00000132005 ENSG00000288283	n/a
UniProt	P22670	n/a
RefSeq (mRNA)	NM_002918	n/a
RefSeq (protein)	NP_002909	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RFX1 yw RFX1 a elwir hefyd yn Regulatory factor X1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RFX1.

• EFC
• RFX

Llyfryddiaeth

• "Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism. ". Eur J Biochem. 2001. PMID 11358531.
• "RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. ". J Biol Chem. 1998. PMID 9733744.
• "Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells. ". J Autoimmun. 2010. PMID 20223637.
• "The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation. ". J Immunol. 2009. PMID 19620312.
• "Identification of an epigenetically silenced gene, RFX1, in human glioma cells using restriction landmark genomic scanning.". Oncogene. 2004. PMID 15334059.