RAPGEF4

RAPGEF4
Dynodwyr
Cyfenwau	RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 4
Dynodwyr allanol	OMIM: 606058 HomoloGene: 4451 GeneCards: RAPGEF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • cAMP binding • GO:0001948, GO:0016582 protein binding • guanyl-nucleotide exchange factor activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • Cellbilen • hippocampal mossy fiber to CA3 synapse Prosesau biolegol • G protein-coupled receptor signaling pathway • GO:0007243 intracellular signal transduction • regulation of insulin secretion • small GTPase mediated signal transduction • insulin secretion • regulation of exocytosis • cAMP-mediated signaling • calcium-ion regulated exocytosis • exocytosis • regulation of synaptic vesicle cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11069	n/a
Ensembl	ENSG00000091428	n/a
UniProt	Q8WZA2	n/a
RefSeq (mRNA)	NM_001100397 NM_001282899 NM_001282900 NM_001282901 NM_007023	n/a
RefSeq (protein)	NP_001093867 NP_001269828 NP_001269829 NP_001269830 NP_008954 NP_001362793 NP_001362794 NP_001362795 NP_001362796 NP_001362797 NP_001362798 NP_001362799 NP_001362800 NP_001362801 NP_001362802 NP_001362803 NP_001362804 NP_001362805	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAPGEF4 yw RAPGEF4 a elwir hefyd yn Rap guanine nucleotide exchange factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAPGEF4.

• EPAC
• CGEF2
• EPAC2
• EPAC*2
• Nbla00496
• CAMP-GEFII

Llyfryddiaeth

• "Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. ". Hippocampus. 2010. PMID 19739231.
• "Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities. ". J Biol Chem. 2009. PMID 19553663.
• "Structure and functional roles of Epac2 (Rapgef4). ". Gene. 2016. PMID 26390815.
• "Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). ". J Biol Chem. 2011. PMID 21454623.
• "Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.". Endocrinology. 2010. PMID 20233795.