RAC1 Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E96 , 1FOE , 1G4U , 1HE1 , 1HH4 , 1I4D , 1I4L , 1I4T , 1MH1 , 1RYF , 1RYH , 2FJU , 2H7V , 2NZ8 , 2P2L , 2RMK , 2VRW , 2WKP , 2WKQ , 2WKR , 2YIN , 3B13 , 3BJI , 3RYT , 3SBD , 3SBE , 3SU8 , 3SUA , 3TH5 , 4GZL , 4GZM , 4YON , 5FI0
Dynodwyr Cyfenwau RAC1 Dynodwyr allanol OMIM: 602048 HomoloGene: 69035 GeneCards: RAC1 Ontoleg y genyn Gweithrediad moleciwlaidd • histone deacetylase binding • Rho GDP-dissociation inhibitor binding • GTP-dependent protein binding • GO:0006184 GTPase activity • enzyme binding • GO:0001948, GO:0016582 protein binding • thioesterase binding • protein kinase binding • nucleotide binding • GTP binding • protein serine/threonine kinase activity • GO:0032403 protein-containing complex binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ATPase binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • focal adhesion • melanosome • ruffle membrane • trans-Golgi network • cnewyllyn cell • cell projection • extrinsic component of plasma membrane • extracellular exosome • lamellipodium • early endosome membrane • Cellbilen • Microffilament • cytoplasmic ribonucleoprotein granule • endoplasmic reticulum membrane • Golgi membrane • phagocytic cup • GO:0016023 cytoplasmic vesicle • GO:0005578 extracellular matrix • secretory granule membrane • dendritic spine • recycling endosome membrane • postsynapse • glutamatergic synapse • ficolin-1-rich granule membrane Prosesau biolegol • positive regulation of Rho protein signal transduction • regulation of respiratory burst • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • positive regulation of actin filament polymerization • regulation of neuron maturation • negative regulation of receptor-mediated endocytosis • platelet activation • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • phagocytosis, engulfment • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • cell population proliferation • ruffle assembly • lamellipodium assembly • dopaminergic neuron differentiation • cell-cell junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • ruffle organization • actin filament organization • cell motility • anatomical structure morphogenesis • bone resorption • response to wounding • protein localization to plasma membrane • inflammatory response • regulation of small GTPase mediated signal transduction • positive regulation of cell-substrate adhesion • G protein-coupled receptor signaling pathway • neuron projection morphogenesis • epithelial cell morphogenesis • dendrite morphogenesis • regulation of hydrogen peroxide metabolic process • engulfment of apoptotic cell • dendrite development • auditory receptor cell morphogenesis • hyperosmotic response • cerebral cortex GABAergic interneuron development • chemotaxis • positive regulation of DNA replication • actin filament polymerization • cell adhesion • negative regulation of interleukin-23 production • homeostasis of number of cells within a tissue • cell-matrix adhesion • localization within membrane • actin cytoskeleton organization • regulation of cell size • anatomical structure arrangement • GO:0007243 intracellular signal transduction • regulation of cell migration • endocytosis • ephrin receptor signaling pathway • T cell costimulation • blood coagulation • GO:0019049, GO:0030683 mitigation of host defenses by virus • synaptic transmission, GABAergic • mast cell chemotaxis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of substrate adhesion-dependent cell spreading • embryonic olfactory bulb interneuron precursor migration • cytoskeleton organization • cochlea morphogenesis • positive regulation of neutrophil chemotaxis • positive regulation of apoptotic process • regulation of cell morphogenesis • positive regulation of focal adhesion assembly • regulation of fibroblast migration • positive regulation of lamellipodium assembly • cerebral cortex radially oriented cell migration • cell migration • semaphorin-plexin signaling pathway • positive regulation of stress fiber assembly • axon guidance • small GTPase mediated signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • Wnt signaling pathway, planar cell polarity pathway • midbrain dopaminergic neuron differentiation • neuron migration • protein phosphorylation • Rho protein signal transduction • regulation of lamellipodium assembly • Rac protein signal transduction • cell projection assembly • positive regulation of microtubule polymerization • neutrophil degranulation • regulation of nitric oxide biosynthetic process • phosphatidylinositol phosphate biosynthetic process • hepatocyte growth factor receptor signaling pathway • regulation of stress fiber assembly • positive regulation of protein kinase B signaling • motor neuron axon guidance • regulation of neutrophil migration • positive regulation of insulin secretion involved in cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn RAC1 yw RAC1 a elwir hefyd yn Rac family small GTPase 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p22.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAC1.
MIG5
MRD48
Rac-1
TC-25
p21-Rac1
"High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast. ". Tumour Biol . 2017. PMID 28671041 . "Emerging roles of RAC1 in treating lung cancer patients. ". Clin Genet . 2017. PMID 27790713 . "Impact of point mutation P29S in RAC1 on tumorigenesis. ". Tumour Biol . 2016. PMID 27699663 . "Rac-ing from Epithelial Secretor to Eater. ". Dev Cell . 2016. PMID 27623380 . "Growth arrest of lung carcinoma cells (A549) by polyacrylate-anchored peroxovanadate by activating Rac1-NADPH oxidase signalling axis. ". Mol Cell Biochem . 2016. PMID 27435854 . 
