POLG2

POLG2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G4C, 3IKL, 3IKM, 4ZTU, 4ZTZ, 5C53, 5C51, 5C52
Dynodwyr
Cyfenwau	POLG2, HP55, MTPOLB, PEOA4, POLB, POLG-BETA, POLGB, polymerase (DNA) gamma 2, accessory subunit, DNA polymerase gamma 2, accessory subunit, MTDPS16, MTDPS16A, MTDPS16B
Dynodwyr allanol	OMIM: 604983 HomoloGene: 5221 GeneCards: POLG2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • DNA binding • nucleotidyltransferase activity • GO:0001948, GO:0016582 protein binding • glycine-tRNA ligase activity • identical protein binding • DNA-directed DNA polymerase activity Cydrannau o'r gell • mitochondrial chromosome • mitochondrial matrix • mitocondria • mitochondrial nucleoid • cytoplasm Prosesau biolegol • DNA-dependent DNA replication • mitochondrial DNA metabolic process • mitochondrion organization • in utero embryonic development • DNA replication • respiratory electron transport chain • mitochondrion morphogenesis • GO:0100026 DNA repair • DNA biosynthetic process • mitochondrial glycyl-tRNA aminoacylation • mitochondrial DNA replication Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11232	n/a
Ensembl	ENSG00000256525	n/a
UniProt	Q9UHN1	n/a
RefSeq (mRNA)	NM_007215	n/a
RefSeq (protein)	NP_009146	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLG2 yw POLG2 a elwir hefyd yn DNA polymerase gamma 2, accessory subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLG2.

• HP55
• POLB
• PEOA4
• POLGB
• MTPOLB
• POLG-BETA

Llyfryddiaeth

• "Biochemical analysis of human POLG2 variants associated with mitochondrial disease. ". Hum Mol Genet. 2011. PMID 21555342.
• "Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity. ". J Biol Chem. 2010. PMID 19858216.
• "Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion. ". Eur J Med Genet. 2016. PMID 27592148.
• "A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits. ". Mitochondrion. 2012. PMID 22155748.
• "A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males.". J Hum Genet. 2011. PMID 21734712.