PKN1

PKN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CXZ, 1URF, 2RMK, 4NKG, 4OTD, 4OTG, 4OTH, 4OTI
Dynodwyr
Cyfenwau	PKN1, DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1, Protein kinase N1
Dynodwyr allanol	OMIM: 601032 HomoloGene: 48130 GeneCards: PKN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • GO:0031493 histone binding • histone deacetylase binding • chromatin binding • histone kinase activity (H3-T11 specific) • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • nuclear receptor coactivator activity • ATP binding • protein kinase C binding Cydrannau o'r gell • cytoplasm • cytosol • endosome • bilen • Cellbilen • nucleoplasm • midbody • cleavage furrow • cnewyllyn cell • GO:0016023 cytoplasmic vesicle • GO:0009327 protein-containing complex Prosesau biolegol • regulation of germinal center formation • GO:0033128 negative regulation of protein phosphorylation • renal system process • GO:0009373 regulation of transcription, DNA-templated • B cell apoptotic process • negative regulation of protein kinase activity • phosphorylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • B cell homeostasis • spleen development • hyperosmotic response • transcription, DNA-templated • regulation of cell motility • protein phosphorylation • GO:0035404 peptidyl-serine phosphorylation • epithelial cell migration • negative regulation of B cell proliferation • regulation of immunoglobulin production • GO:0072468 signal transduction • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of nucleic acid-templated transcription • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5585	n/a
Ensembl	ENSG00000123143	n/a
UniProt	Q16512	n/a
RefSeq (mRNA)	NM_002741 NM_213560	n/a
RefSeq (protein)	NP_002732 NP_998725	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PKN1 yw PKN1 a elwir hefyd yn Serine/threonine-protein kinase N1 a Protein kinase N1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PKN1.

• DBK
• PKN
• PAK1
• PRK1
• PAK-1
• PRKCL1
• PKN-ALPHA

Llyfryddiaeth

• "PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma. ". Hum Pathol. 2009. PMID 19427017.
• "Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport. ". FEBS Lett. 2008. PMID 18519042.
• "PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. ". Oncotarget. 2014. PMID 25504435.
• "Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. ". Mol Cell Biol. 2014. PMID 24248594.
• "Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.". J Biol Chem. 2013. PMID 24114839.