PGK1

PGK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2WZB, 2WZC, 2WZD, 2X13, 2X14, 2X15, 2XE6, 2XE7, 2XE8, 2Y3I, 2YBE, 2ZGV, 3C39, 3C3A, 3C3B, 3C3C, 3ZOZ, 4AXX, 4O33
Dynodwyr
Cyfenwau	PGK1, HEL-S-68p, MIG10, PGKA, phosphoglycerate kinase 1
Dynodwyr allanol	OMIM: 311800 HomoloGene: 21542 GeneCards: PGK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • GO:0001948, GO:0016582 protein binding • ATP binding • kinase activity • phosphoglycerate kinase activity • protein-disulfide reductase (NAD(P)) activity • ADP binding Cydrannau o'r gell • cytoplasm • membrane raft • cytosol • extracellular exosome • bilen • extracellular space Prosesau biolegol • gluconeogenesis • epithelial cell differentiation • phosphorylation • canonical glycolysis • glycolytic process • negative regulation of angiogenesis • plasminogen activation • cellular response to hypoxia • response to hypoxia • chemical synaptic transmission • myoblast fusion • somatic muscle development • muscle cell cellular homeostasis • positive regulation of oxidative phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5230	n/a
Ensembl	ENSG00000102144	n/a
UniProt	P00558	n/a
RefSeq (mRNA)	NM_000291	n/a
RefSeq (protein)	NP_000282	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PGK1 yw PGK1 a elwir hefyd yn Phosphoglycerate kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PGK1.

• PGKA
• MIG10
• HEL-S-68p

Llyfryddiaeth

• "Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer. ". Br J Cancer. 2015. PMID 25867275.
• "Downregulation of phosphoglycerate kinase 1 by shRNA sensitizes U251 xenografts to radiotherapy. ". Oncol Rep. 2014. PMID 25175369.
• "PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis. ". Inflamm Res. 2016. PMID 27342824.
• "Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. ". Mol Cell. 2016. PMID 26942675.
• "A negative waveform in the scotopic response in a patient with phosphoglycerate kinase deficiency: a visual electrophysiology report.". Doc Ophthalmol. 2015. PMID 26396085.