PFN2

PFN2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1D1J
Dynodwyr
Cyfenwau	PFN2, D3S1319E, PFL, profilin 2
Dynodwyr allanol	OMIM: 176590 HomoloGene: 1974 GeneCards: PFN2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • actin binding • phosphatidylinositol-4,5-bisphosphate binding • actin monomer binding • GO:0001948, GO:0016582 protein binding • ATPase activity Cydrannau o'r gell • cytoplasm • terminal bouton • extracellular exosome • Cytosgerbwd • Schaffer collateral - CA1 synapse • presynapse • postsynapse • glutamatergic synapse Prosesau biolegol • regulation of actin filament polymerization • regulation of synaptic vesicle exocytosis • protein stabilization • positive regulation of actin filament bundle assembly • positive regulation of actin filament polymerization • negative regulation of actin filament polymerization • positive regulation of ATP-dependent activity • negative regulation of epithelial cell migration • positive regulation of stress fiber assembly • actin cytoskeleton organization • positive regulation of peptidyl-serine phosphorylation • negative regulation of ruffle assembly • modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5217	n/a
Ensembl	ENSG00000070087	n/a
UniProt	P35080	n/a
RefSeq (mRNA)	NM_053024 NM_002628	n/a
RefSeq (protein)	NP_002619 NP_444252	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PFN2 yw PFN2 a elwir hefyd yn Profilin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PFN2.

• PFL
• D3S1319E

Llyfryddiaeth

• "Decreased expression of profilin 2 in oral squamous cell carcinoma and its clinicopathological implications. ". Oncol Rep. 2011. PMID 21725608.
• "Cloning and expression of a novel human profilin variant, profilin II. ". FEBS Lett. 1993. PMID 8365484.
• "PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma. ". J Transl Med. 2016. PMID 27188458.
• "Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis. ". Nat Commun. 2015. PMID 26354229.
• "Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells.". Biosci Biotechnol Biochem. 2015. PMID 25964982.