PDK1

PDK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2Q8F, 2Q8G, 2Q8H
Dynodwyr
Cyfenwau	PDK1, entrez:5163, pyruvate dehydrogenase kinase 1
Dynodwyr allanol	OMIM: 602524 HomoloGene: 134437 GeneCards: PDK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • pyruvate dehydrogenase (acetyl-transferring) kinase activity Cydrannau o'r gell • mitochondrial pyruvate dehydrogenase complex • mitochondrial matrix • cnewyllyn cell • nucleolus • mitocondria Prosesau biolegol • intrinsic apoptotic signaling pathway in response to oxidative stress • phosphorylation • hypoxia-inducible factor-1alpha signaling pathway • regulation of acetyl-CoA biosynthetic process from pyruvate • regulation of glucose metabolic process • glucose metabolic process • cell population proliferation • protein phosphorylation • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5163	n/a
Ensembl	ENSG00000152256	n/a
UniProt	Q15118	n/a
RefSeq (mRNA)	NM_001278549 NM_002610	n/a
RefSeq (protein)	NP_001265478 NP_002601	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDK1 yw PDK1 a elwir hefyd yn Pyruvate dehydrogenase kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q31.1.

Llyfryddiaeth

• "Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. ". PLoS One. 2017. PMID 28617852.
• "Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer. ". Cancer Res. 2017. PMID 28249908.
• "Frequent overexpression of PDK1 in primary nasopharyngeal carcinoma is associated with poor prognosis. ". Pathol Res Pract. 2016. PMID 28029432.
• "PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer. ". Oncol Rep. 2017. PMID 27878287.
• "Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth.". Oncotarget. 2016. PMID 26593251.