PAM

PAM
Dynodwyr
Cyfenwau	PAM, PAL, PHM, Peptidylglycine alpha-amidating monooxygenase
Dynodwyr allanol	OMIM: 170270 HomoloGene: 37369 GeneCards: PAM
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • calcium ion binding • copper ion binding • lyase activity • protein kinase binding • monooxygenase activity • catalytic activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen • L-ascorbic acid binding • GO:0001948, GO:0016582 protein binding • zinc ion binding • peptidylglycine monooxygenase activity • peptidylamidoglycolate lyase activity Cydrannau o'r gell • extracellular exosome • extracellular region • integral component of membrane • trans-Golgi network • neuron projection • cell surface • neuronal cell body • perinuclear region of cytoplasm • Cellbilen • secretory granule membrane • secretory granule • perikaryon • bilen • extracellular space • transport vesicle membrane • GO:0016023 cytoplasmic vesicle Prosesau biolegol • response to hypoxia • limb development • ovulation cycle process • odontogenesis • regulation of protein secretion • response to estradiol • regulation of actin cytoskeleton organization • maternal process involved in female pregnancy • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • metabolaeth • protein homooligomerization • response to copper ion • heart development • central nervous system development • toxin metabolic process • response to pH • response to glucocorticoid • GO:0018033, GO:0018053, GO:0018050, GO:0018051, GO:0018052, GO:0018042, GO:0018043, GO:0018044, GO:0018045, GO:0018046, GO:0018047, GO:0018048, GO:0018049, GO:0018040, GO:0018170, GO:0018041, GO:0018034, GO:0018035, GO:0018036, GO:0018037, GO:0018038, GO:0018039 protein amidation • GO:0044267 protein metabolic process • long-chain fatty acid metabolic process • peptide metabolic process • lactation • peptide amidation • fatty acid primary amide biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5066	n/a
Ensembl	ENSG00000145730	n/a
UniProt	P19021	n/a
RefSeq (mRNA)	NM_000919 NM_001177306 NM_138766 NM_138821 NM_138822 NM_001319943	n/a
RefSeq (protein)	NP_000910 NP_001170777 NP_001306872 NP_620121 NP_620176 NP_620177 NP_001351511 NP_001351512 NP_001351513 NP_001351514 NP_001351515 NP_001351516 NP_001351517 NP_001351518 NP_001351519 NP_001351520 NP_001351521 NP_001351522 NP_001351523	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAM yw PAM a elwir hefyd yn Peptidyl-glycine alpha-amidating monooxygenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAM.

• PAL
• PHM

Llyfryddiaeth

• "Stopped-Flow Studies of the Reduction of the Copper Centers Suggest a Bifurcated Electron Transfer Pathway in Peptidylglycine Monooxygenase. ". Biochemistry. 2016. PMID 26982589.
• "Production of the catalytic core of human peptidylglycine α-hydroxylating monooxygenase (hPHMcc) in Escherichia coli. ". Protein Expr Purif. 2012. PMID 22554821.
• "A copper-methionine interaction controls the pH-dependent activation of peptidylglycine monooxygenase. ". Biochemistry. 2011. PMID 22080626.
• "The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?". ChemMedChem. 2009. PMID 19693765.
• "Immunocytochemical finding of the amidating enzymes in mouse pancreatic A-, B-, and D-cells: a comparison with human and rat.". J Histochem Cytochem. 2002. PMID 12364573.