NR4A2

NR4A2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OVL
Dynodwyr
Cyfenwau	NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR, nuclear receptor subfamily 4 group A member 2
Dynodwyr allanol	OMIM: 601828 HomoloGene: 4509 GeneCards: NR4A2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • retinoid X receptor binding • protein homodimerization activity • sequence-specific DNA binding • beta-catenin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • steroid hormone receptor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • glucocorticoid receptor binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • DNA binding • protein heterodimerization activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm • nuclear speck • transcription regulator complex Prosesau biolegol • dopaminergic neuron differentiation • cellular response to oxidative stress • response to hypoxia • response to amphetamine • nervous system development • neuron maturation • steroid hormone mediated signaling pathway • central nervous system projection neuron axonogenesis • GO:0009373 regulation of transcription, DNA-templated • central nervous system neuron differentiation • negative regulation of apoptotic signaling pathway • cellular response to corticotropin-releasing hormone stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of respiratory gaseous exchange • regulation of dopamine metabolic process • adult locomotory behavior • regulation of gene expression • habenula development • GO:0048554 positive regulation of catalytic activity • fat cell differentiation • post-embryonic development • dopamine biosynthetic process • transcription initiation from RNA polymerase II promoter • GO:1904089 negative regulation of neuron apoptotic process • canonical Wnt signaling pathway • general adaptation syndrome • neuron differentiation • GO:0072468 signal transduction • dopamine metabolic process • transcription, DNA-templated • intracellular receptor signaling pathway • neuron migration • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to extracellular stimulus • midbrain dopaminergic neuron differentiation • gene expression • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4929	n/a
Ensembl	ENSG00000153234	n/a
UniProt	P43354	n/a
RefSeq (mRNA)	NM_006186 NM_173171 NM_173172 NM_173173	n/a
RefSeq (protein)	NP_006177 NP_775265 NP_006177.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NR4A2 yw NR4A2 a elwir hefyd yn Nuclear receptor related 1 a Nuclear receptor subfamily 4 group A member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NR4A2.

• NOT
• RNR1
• HZF-3
• NURR1
• TINUR

Llyfryddiaeth

• "cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome. ". Clin Exp Immunol. 2017. PMID 28621822.
• "Haploinsufficiency of NR4A2 is associated with a neurodevelopmental phenotype with prominent language impairment. ". Am J Med Genet A. 2017. PMID 28544326.
• "Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1. ". ACS Chem Biol. 2016. PMID 27128111.
• "Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells. ". Neurotox Res. 2016. PMID 26678495.
• "Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes.". Mol Med Rep. 2015. PMID 26239742.