NFKB2

NFKB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A3Q, 2D96, 3DO7, 4OT9
Dynodwyr
Cyfenwau	NFKB2, CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52, p100, p49/p100, nuclear factor kappa B subunit 2
Dynodwyr allanol	OMIM: 164012 HomoloGene: 1873 GeneCards: NFKB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001105 transcription coactivator activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • Bcl3/NF-kappaB2 complex • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • response to cytokine • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • germinal center formation • GO:0010260 heneiddio • extracellular matrix organization • GO:1901227 negative regulation of transcription by RNA polymerase II • spleen development • transcription, DNA-templated • follicular dendritic cell differentiation • response to lipopolysaccharide • NIK/NF-kappaB signaling • positive regulation of NF-kappaB transcription factor activity • inflammatory response • I-kappaB kinase/NF-kappaB signaling • positive regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • transcription by RNA polymerase II • innate immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4791	n/a
Ensembl	ENSG00000077150	n/a
UniProt	Q00653	n/a
RefSeq (mRNA)	NM_001077494 NM_001261403 NM_001288724 NM_002502 NM_001322934 NM_001322935	n/a
RefSeq (protein)	NP_001070962 NP_001248332 NP_001275653 NP_001309863 NP_001309864 NP_002493	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NFKB2 yw NFKB2 a elwir hefyd yn Nuclear factor kappa B subunit 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q24.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFKB2.

• p52
• p100
• H2TF1
• LYT10
• CVID10
• LYT-10
• NF-kB2
• p49/p100

Llyfryddiaeth

• "Novel nonsense gain-of-function NFKB2mutations associated with a combined immunodeficiency phenotype. ". Blood. 2017. PMID 28778864.
• "NFκB2 Gene as a Novel Candidate that Epigenetically Responds to Interval Walking Training. ". Int J Sports Med. 2015. PMID 25901949.
• "Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies. ". BMC Med Genet. 2014. PMID 25524009.
• "Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. ". Blood. 2014. PMID 25237204.
• "NFκB2/p100 is a key factor for endotoxin tolerance in human monocytes: a demonstration using primary human monocytes from patients with sepsis.". J Immunol. 2014. PMID 25225662.