NCF2

NCF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E96, 1HH8, 1K4U, 1OEY, 1WM5, 2DMO
Dynodwyr
Cyfenwau	NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX, Neutrophil cytosolic factor 2
Dynodwyr allanol	OMIM: 608515 HomoloGene: 374 GeneCards: NCF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • superoxide-generating NAD(P)H oxidase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • electron transfer activity • superoxide-generating NADPH oxidase activator activity Cydrannau o'r gell • acrosomal vesicle • nucleolus • phagolysosome • cytoplasm • cytosol • NADPH oxidase complex Prosesau biolegol • superoxide anion generation • cellular defense response • vascular endothelial growth factor receptor signaling pathway • innate immune response • superoxide metabolic process • ffagocytosis • GO:0048554 positive regulation of catalytic activity • respiratory burst • electron transport chain • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • cellular response to oxidative stress • cell redox homeostasis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4688	n/a
Ensembl	ENSG00000116701	n/a
UniProt	P19878	n/a
RefSeq (mRNA)	NM_000433 NM_001127651 NM_001190789 NM_001190794	n/a
RefSeq (protein)	NP_000424 NP_001121123 NP_001177718 NP_001177723	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NCF2 yw NCF2 a elwir hefyd yn Neutrophil cytosolic factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NCF2.

• NCF-2
• NOXA2
• P67PHOX
• P67-PHOX

Llyfryddiaeth

• "Chronic Granulomatous Disease Due to Neutrophil Cytosolic Factor (NCF2) Gene Mutations in Three Unrelated Families. ". J Clin Immunol. 2017. PMID 28035544.
• "A Founder Effect of c.257 + 2T > C Mutation in NCF2 Gene Underlies Severe Chronic Granulomatous Disease in Eleven Patients. ". J Clin Immunol. 2016. PMID 27220316.
• "A novel mutation in NCF2 associated with autoimmune disease and a solitary late-onset infection. ". Clin Immunol. 2015. PMID 26272171.
• "Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex. ". J Biol Chem. 2015. PMID 25795782.
• "Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.". Hum Mol Genet. 2014. PMID 24163247.