MYLK

MYLK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CQV, 2K0F, 2YR3
Dynodwyr
Cyfenwau	MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK, myosin light chain kinase, MMIHS, MMIHS1, MYLK-L
Dynodwyr allanol	OMIM: 600922 HomoloGene: 14202 GeneCards: MYLK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • metal ion binding • calmodulin binding • myosin light chain kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • actin binding • ATP binding Cydrannau o'r gell • cytoplasm • cytosol • cell projection • stress fiber • cleavage furrow • Cytosgerbwd • lamellipodium • Cellbilen • actin cytoskeleton Prosesau biolegol • smooth muscle contraction • muscle contraction • phosphorylation • tonic smooth muscle contraction • positive regulation of cell migration • positive regulation of wound healing • bleb assembly • cellular hypotonic response • protein phosphorylation • aorta smooth muscle tissue morphogenesis • positive regulation of calcium ion transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4638	n/a
Ensembl	ENSG00000065534	n/a
UniProt	Q15746	n/a
RefSeq (mRNA)	NM_001321309 NM_005965 NM_053025 NM_053026 NM_053027 NM_053028 NM_053029 NM_053030 NM_053031 NM_053032	n/a
RefSeq (protein)	NP_001308238 NP_444253 NP_444254 NP_444255 NP_444256 NP_444259 NP_444260	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MYLK yw MYLK a elwir hefyd yn Myosin light chain kinase, smooth muscle a Myosin light chain kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MYLK.

• KRP
• AAT7
• MLCK
• MLCK1
• MYLK1
• smMLCK
• MLCK108
• MLCK210
• MSTP083

Llyfryddiaeth

• "Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome. ". Am J Hum Genet. 2017. PMID 28602422.
• "Myosin Light Chain Kinase MYLK1: Anatomy, Interactions, Functions, and Regulation. ". Biochemistry (Mosc). 2016. PMID 28260490.
• "A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description. ". BMC Med Genet. 2016. PMID 27586135.
• "Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. ". Transl Res. 2017. PMID 27543902.
• "Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene.". Am J Respir Cell Mol Biol. 2017. PMID 27529643.