MC4R

MC4R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IQP, 2IQR, 2IQS, 2IQU, 2IQV, 2IQW
Dynodwyr
Cyfenwau	MC4R, Melanocortin 4 receptor, BMIQ20
Dynodwyr allanol	OMIM: 155541 HomoloGene: 4320 GeneCards: MC4R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • signal transducer activity • peptide hormone binding • melanocyte-stimulating hormone receptor activity • GO:0001948, GO:0016582 protein binding • melanocortin receptor activity • ubiquitin protein ligase binding • neuropeptide binding • hormone binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • cnewyllyn cell Prosesau biolegol • regulation of grooming behavior • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • insulin secretion • regulation of feeding behavior • positive regulation of bone resorption • diet induced thermogenesis • response to insulin • feeding behavior • negative regulation of feeding behavior • energy reserve metabolic process • regulation of metabolic process • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4160	n/a
Ensembl	ENSG00000166603	n/a
UniProt	P32245	n/a
RefSeq (mRNA)	NM_005912	n/a
RefSeq (protein)	NP_005903	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MC4R yw MC4R a elwir hefyd yn Melanocortin 4 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.32.

Llyfryddiaeth

• "Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population. ". PLoS One. 2017. PMID 28520814.
• "Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4Rgene in postmenopausal women. ". Clin Interv Aging. 2017. PMID 28356726.
• "Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents. ". PLoS One. 2017. PMID 28081251.
• "Association of the melanocortin 4 receptor gene rs17782313 polymorphism with rewarding value of food and eating behavior in Chilean children. ". J Physiol Biochem. 2017. PMID 27730429.
• "A Common Variant and the Transcript Levels of MC4R Gene Are Associated With Adiposity in Children: The IDEFICS Study.". J Clin Endocrinol Metab. 2016. PMID 27583473.