LHX2

LHX2
Dynodwyr
Cyfenwau	LHX2, LH2, hLhx2, LIM homeobox 2
Dynodwyr allanol	OMIM: 603759 HomoloGene: 55848 GeneCards: LHX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • sequence-specific DNA binding • chromatin binding • DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • intracellular anatomical structure Prosesau biolegol • negative regulation of transcription regulatory region DNA binding • mesoderm development • telencephalon development • neural tube closure • retina development in camera-type eye • cerebral cortex development • transcription, DNA-templated • axon guidance • axon extension • hair follicle development • maintenance of epithelial cell apical/basal polarity • neurogenesis • brain development • olfactory bulb development • nervous system development • dorsal/ventral pattern formation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • neuron differentiation • anatomical structure formation involved in morphogenesis • telencephalon regionalization • transcription by RNA polymerase II • negative regulation of gene expression, epigenetic • negative regulation of neurogenesis • positive regulation of neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9355	n/a
Ensembl	ENSG00000106689	n/a
UniProt	P50458	n/a
RefSeq (mRNA)	NM_004789	n/a
RefSeq (protein)	NP_004780	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LHX2 yw LHX2 a elwir hefyd yn LIM homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q33.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LHX2.

• LH2
• hLhx2

Llyfryddiaeth

• "Mutations in the LHX2 gene are not a frequent cause of micro/anophthalmia. ". Mol Vis. 2010. PMID 21203406.
• "Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. ". Oncogene. 1996. PMID 8649822.
• "Oncogenicity of LHX2 in pancreatic ductal adenocarcinoma. ". Mol Biol Rep. 2014. PMID 25324171.
• "LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. ". Nucleic Acids Res. 2013. PMID 23804753.
• "Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities.". Eur J Endocrinol. 2012. PMID 22535646.