ITGB3

ITGB3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
Dynodwyr
Cyfenwau	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
Dynodwyr allanol	OMIM: 173470 HomoloGene: 55444 GeneCards: ITGB3
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• vascular endothelial growth factor receptor 2 binding; • fibronectin binding; • virus receptor activity; • extracellular matrix binding; • GO:0030508 protein disulfide isomerase activity; • protease binding; • platelet-derived growth factor receptor binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • enzyme binding; • cell adhesion molecule binding; • neuregulin binding; • coreceptor activity; • fibroblast growth factor binding; • insulin-like growth factor I binding; • C-X3-C chemokine binding; • integrin binding; • fibrinogen binding;
Cydrannau o'r gell	• integral component of membrane; • cell projection; • alphav-beta3 integrin-vitronectin complex; • bilen; • focal adhesion; • melanosome; • receptor complex; • Cellbilen; • integral component of plasma membrane; • ruffle membrane; • cell surface; • cell junction; • integrin complex; • platelet alpha granule membrane; • integrin alphav-beta3 complex; • extracellular exosome; • lamellipodium membrane; • cnewyllyn cell; • microvillus membrane; • filopodium membrane; • alphav-beta3 integrin-IGF-1-IGF1R complex; • alphav-beta3 integrin-PKCalpha complex; • alphav-beta3 integrin-HMGB1 complex; • glutamatergic synapse; • synapse;
Prosesau biolegol	• negative regulation of lipoprotein metabolic process; • apolipoprotein A-I-mediated signaling pathway; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein phosphorylation; • regulation of cell migration; • negative chemotaxis; • positive regulation of endothelial cell proliferation; • tube development; • heterotypic cell-cell adhesion; • angiogenesis involved in wound healing; • wound healing; • platelet degranulation; • blood coagulation; • extracellular matrix organization; • smooth muscle cell migration; • positive regulation of endothelial cell migration; • cell growth; • cell-substrate adhesion; • vascular endothelial growth factor receptor signaling pathway; • cell adhesion; • positive regulation of peptidyl-tyrosine phosphorylation; • mesodermal cell differentiation; • cell-substrate junction assembly; • integrin-mediated signaling pathway; • negative regulation of lipid storage; • substrate adhesion-dependent cell spreading; • negative regulation of lipid transport; • cell-matrix adhesion; • GO:0022415 viral process; • regulation of bone resorption; • platelet aggregation; • cell migration; • negative regulation of macrophage derived foam cell differentiation; • activation of protein kinase activity; • leukocyte migration; • cell adhesion mediated by integrin; • platelet activation; • apoptotic cell clearance; • regulation of postsynaptic neurotransmitter receptor internalization; • regulation of protein localization; • regulation of serotonin uptake;
	Sources:Amigo / QuickGO
Orthologau
	3690
	n/a
	ENSG00000259207
	n/a
	P05106
	n/a
	NM_000212
	n/a
	NP_000203
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGB3 yw ITGB3 a elwir hefyd yn Integrin subunit beta 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGB3.

GT
CD61
GP3A
BDPLT2
GPIIIa
BDPLT16

Llyfryddiaeth

"Cancer-associated fibroblasts lead tumor invasion through integrin-β3-dependent fibronectin assembly. ". J Cell Biol. 2017. PMID 28931556.
"Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. ". Cell Rep. 2017. PMID 28273461.
"[Application of recombinant GPâ…¢a combined Luminex beads for the detection of HPA-1a antibody]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28186591.
"Overexpression of CD61 promotes hUC-MSC differentiation into male germ-like cells. ". Cell Prolif. 2016. PMID 26840189.
"[Study of in vitro expression of human platelet ITGB3 gene nonsense mutation c.1476G>A].". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016. PMID 26829726.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ITGB3 - Cronfa NCBI

[1]

[2]