INSR

INSR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2HR7, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3W11, 3W12, 3W13, 3W14, 2MFR, 2Z8C, 4IBM, 4OGA, 4XLV, 4XST, 5E1S, 4ZXB, 5J3H, 5HHW
Dynodwyr
Cyfenwau	INSR, CD220, HHF5, insulin receptor
Dynodwyr allanol	OMIM: 147670 HomoloGene: 20090 GeneCards: INSR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • kinase activity • insulin-like growth factor II binding • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein kinase activity • insulin-like growth factor receptor binding • insulin receptor substrate binding • transferase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • nucleotide binding • insulin-like growth factor I binding • GTP binding • PTB domain binding • phosphatidylinositol 3-kinase binding • insulin binding • insulin-activated receptor activity • protein domain specific binding • amyloid-beta binding • cargo receptor activity • GO:0032403 protein-containing complex binding Cydrannau o'r gell • bilen • caveola • insulin receptor complex • extracellular exosome • integral component of membrane • receptor complex • Cellbilen • endosome membrane • integral component of plasma membrane • intracellular anatomical structure • nuclear envelope • external side of plasma membrane • axon • nuclear lumen • dendrite membrane • neuronal cell body membrane Prosesau biolegol • positive regulation of glucose import • GO:1901047 insulin receptor signaling pathway • positive regulation of protein phosphorylation • regulation of embryonic development • positive regulation of developmental growth • protein phosphorylation • regulation of female gonad development • animal organ morphogenesis • transformation of host cell by virus • positive regulation of mitotic nuclear division • positive regulation of meiotic cell cycle • positive regulation of protein kinase B signaling • positive regulation of glycogen biosynthetic process • GO:0009373 regulation of transcription, DNA-templated • transmembrane receptor protein tyrosine kinase signaling pathway • male sex determination • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • epidermis development • cellular response to insulin stimulus • protein autophosphorylation • positive regulation of respiratory burst • positive regulation of MAPK cascade • exocrine pancreas development • G protein-coupled receptor signaling pathway • male gonad development • phosphorylation • carbohydrate metabolic process • positive regulation of DNA replication • peptidyl-tyrosine autophosphorylation • activation of protein kinase B activity • positive regulation of cell migration • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • heart morphogenesis • adrenal gland development • positive regulation of cell population proliferation • positive regulation of glycolytic process • activation of protein kinase activity • GO:0072468 signal transduction • glucose homeostasis • peptidyl-tyrosine phosphorylation • protein heterotetramerization • GO:0007243 intracellular signal transduction • receptor-mediated endocytosis • learning • Cof • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of protein-containing complex disassembly • GO:1903374 anatomical structure development • dendritic spine maintenance • amyloid-beta clearance • neuron projection maintenance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3643	n/a
Ensembl	ENSG00000171105	n/a
UniProt	P06213	n/a
RefSeq (mRNA)	NM_000208 NM_001079817	n/a
RefSeq (protein)	NP_000199 NP_001073285	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn INSR yw INSR a elwir hefyd yn Insulin receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn INSR.

• HHF5
• CD220

Llyfryddiaeth

• "Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle. ". PLoS One. 2017. PMID 28915272.
• "INSR gene polymorphisms correlate with sensitivity to platinum-based chemotherapy and prognosis in patients with epithelial ovarian cancer. ". Gene Ther. 2017. PMID 28436941.
• "Inverse relationship between insulin receptor expression and progression in renal cell carcinoma. ". Oncol Rep. 2017. PMID 28393204.
• "Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein. ". Mol Pharm. 2017. PMID 28279069.
• "The INSR rs2059806 single nucleotide polymorphism, a genetic risk factor for vascular and metabolic disease, associates with pre-eclampsia.". Reprod Biomed Online. 2017. PMID 28117222.