IL1B Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HIB , 1I1B , 1IOB , 1ITB , 1L2H , 1S0L , 1T4Q , 1TOO , 1TP0 , 1TWE , 1TWM , 21BI , 2I1B , 2KH2 , 2NVH , 31BI , 3O4O , 3POK , 41BI , 4DEP , 4G6J , 4G6M , 4GAI , 4I1B , 5I1B , 6I1B , 7I1B , 9ILB , 4GAF , 5BVP
Dynodwyr Cyfenwau IL1B Dynodwyr allanol OMIM: 147720 HomoloGene: 481 GeneCards: IL1B Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • interleukin-1 receptor binding • cytokine activity • integrin binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • extracellular region • lysosome • extracellular exosome • secretory granule • fesigl • extracellular space Prosesau biolegol • positive regulation of protein phosphorylation • smooth muscle adaptation • positive regulation of calcidiol 1-monooxygenase activity • GO:1903105 negative regulation of insulin receptor signaling pathway • cellular response to mechanical stimulus • positive regulation of interleukin-8 production • positive regulation of mitotic nuclear division • response to carbohydrate • embryo implantation • regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of cell population proliferation • GO:0097285 apoptotic process • cellular response to organic substance • positive regulation of phagocytosis • regulation of insulin secretion • neutrophil chemotaxis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of protein export from nucleus • positive regulation of prostaglandin secretion • positive regulation of myosin light chain kinase activity • negative regulation of MAP kinase activity • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • inflammatory response • negative regulation of lipid metabolic process • sequestering of triglyceride • hyaluronan biosynthetic process • positive regulation of heterotypic cell-cell adhesion • positive regulation of lipid catabolic process • GO:1904579 cellular response to organic cyclic compound • positive regulation of fever generation • positive regulation of DNA-binding transcription factor activity • positive regulation of angiogenesis • response to lipopolysaccharide • positive regulation of NF-kappaB transcription factor activity • positive regulation of granulocyte macrophage colony-stimulating factor production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • ectopic germ cell programmed cell death • leukocyte migration • lipopolysaccharide-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of cell adhesion molecule production • response to ATP • monocyte aggregation • protein kinase B signaling • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • positive regulation of monocyte chemotactic protein-1 production • regulation of nitric-oxide synthase activity • positive regulation of membrane protein ectodomain proteolysis • positive regulation of interferon-gamma production • MAPK cascade • positive regulation of histone acetylation • GO:1901313 positive regulation of gene expression • negative regulation of glucose transmembrane transport • interleukin-1 beta production • positive regulation of T cell mediated immunity • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of vascular endothelial growth factor production • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of lipid catabolic process • negative regulation of adiponectin secretion • regulation of establishment of endothelial barrier • positive regulation of cell division • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cytokine-mediated signaling pathway • regulation of defense response to virus by host • fever generation • positive regulation of JNK cascade • positive regulation of cell population proliferation • regulation of signaling receptor activity • positive regulation of epithelial to mesenchymal transition • positive regulation of cell migration • interleukin-6 production • astrocyte activation • regulation of neurogenesis • negative regulation of neurogenesis • negative regulation of synaptic transmission • positive regulation of glial cell proliferation • regulation of ERK1 and ERK2 cascade • interleukin-1-mediated signaling pathway • cellular response to lipopolysaccharide • positive regulation of neuroinflammatory response • positive regulation of p38MAPK cascade • positive regulation of NIK/NF-kappaB signaling • positive regulation of T-helper 1 cell cytokine production • positive regulation of prostaglandin biosynthetic process • positive regulation of complement activation • positive regulation of inflammatory response • response to interleukin-1 • positive regulation of RNA biosynthetic process Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn IL1B yw IL1B a elwir hefyd yn Interleukin 1 beta (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q14.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL1B.
"Interleukin-1beta (IL-1β)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1β on human dystrophic myogenic cells. ". PLoS One . 2017. PMID 29194448 . "Association of polymorphic variants in IL1B gene with secretion of IL-1β protein and inflammatory markers in north Indian rheumatoid arthritis patients. ". Gene . 2018. PMID 29054755 . "Predisposition of IL-1β (-511 C/T) polymorphism to renal and hematologic disorders in Indian SLE patients. ". Gene . 2018. PMID 29032148 . "Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin. ". Immunology . 2018. PMID 28777886 . "Genetic variability of interleukin-1 beta as prospective factor from developing post-traumatic stress disorder. ". Immunogenetics . 2017. PMID 28681202 . 
