IFNA2

IFNA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1RH2, 3S9D, 1ITF, 2LAG, 4YPG, 2KZ1, 2HYM, 2LMS, 3SE3, 4Z5R
Dynodwyr
Cyfenwau	IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2, interferon, alpha 2, interferon alpha 2, IFN-alpha-2, leIF A
Dynodwyr allanol	OMIM: 147562 HomoloGene: 86655 GeneCards: IFNA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • type I interferon receptor binding • GO:0001948, GO:0016582 protein binding • GO:0005145 cytokine receptor binding Cydrannau o'r gell • extracellular region • extracellular space • collagen-containing extracellular matrix Prosesau biolegol • GO:0097285 apoptotic process • defense response • negative regulation of viral entry into host cell • response to exogenous dsRNA • cell-cell signaling • negative regulation of T-helper 2 cell cytokine production • blood coagulation • positive regulation of peptidyl-serine phosphorylation of STAT protein • negative regulation of gene expression • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • natural killer cell activation involved in immune response • cell surface receptor signaling pathway • B cell proliferation • humoral immune response • type I interferon signaling pathway • B cell differentiation • positive regulation of phosphorylation • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of T cell differentiation • T cell activation involved in immune response • defense response to virus • innate immune response • cytokine-mediated signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • adaptive immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3440	n/a
Ensembl	ENSG00000188379	n/a
UniProt	P01563	n/a
RefSeq (mRNA)	NM_000605	n/a
RefSeq (protein)	NP_000596	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IFNA2 yw IFNA2 a elwir hefyd yn Interferon alpha 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IFNA2.

• IFNA
• INFA2
• IFNA2B
• IFN-alphaA

Llyfryddiaeth

• "Mutations in Human Interferon α2b Gene and Potential as Risk Factor Associated with Female Breast Cancer. ". Cancer Biother Radiopharm. 2016. PMID 27403569.
• "Biased expression, under the control of single promoter, of human interferon α-2b and Escherichia coli methionine amino peptidase genes in E. coli, irrespective of their distance from the promoter. ". Pak J Pharm Sci. 2016. PMID 27087087.
• "IFNA2: The prototypic human alpha interferon. ". Gene. 2015. PMID 25982860.
• "Mutations of the human interferon alpha-2b gene in brain tumor patients exposed to different environmental conditions. ". Cancer Gene Ther. 2015. PMID 25837663.
• "Mutations of the human interferon alpha-2b (hIFN-α2b) gene in occupationally protracted low dose radiation exposed personnel.". Cytokine. 2015. PMID 25768396.