IFI16

IFI16
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OQ0, 3B6Y, 3RLN, 3RLO, 3RNU, 4QGU
Dynodwyr
Cyfenwau	IFI16, IFNGIP1, PYHIN2, interferon gamma inducible protein 16
Dynodwyr allanol	OMIM: 147586 HomoloGene: 115929 GeneCards: IFI16
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • identical protein binding • double-stranded DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • RNA binding Cydrannau o'r gell • nucleolus • nucleoplasm • cnewyllyn cell • bilen • nuclear speck • cytoplasm • cytosol Prosesau biolegol • positive regulation of type I interferon production • GO:0032737 positive regulation of cytokine production • intrinsic apoptotic signaling pathway by p53 class mediator • cellular response to glucose starvation • transcription, DNA-templated • negative regulation of viral genome replication • negative regulation of innate immune response • monocyte differentiation • cellular response to ionizing radiation • negative regulation of DNA binding • regulation of autophagy • myeloid cell differentiation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • GO:0097285 apoptotic process • hemopoiesis • activation of cysteine-type endopeptidase activity • autophagy • negative regulation of cysteine-type endopeptidase activity • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of interleukin-1 beta production • GO:0009373 regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • activation of innate immune response • immune system process • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • innate immune response • defense response to virus • cellular response to interferon-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3428	n/a
Ensembl	ENSG00000163565	n/a
UniProt	Q16666	n/a
RefSeq (mRNA)	NM_001206567 NM_005531 NM_001364867 NM_001376587 NM_001376588 NM_001376589 NM_001376591 NM_001376592	n/a
RefSeq (protein)	NP_001193496 NP_005522 NP_001351796 NP_001363516 NP_001363517 NP_001363518 NP_001363520 NP_001363521	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IFI16 yw IFI16 a elwir hefyd yn Gamma-interferon-inducible protein 16 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IFI16.

• PYHIN2
• IFNGIP1

Llyfryddiaeth

• "IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome. ". Cell Prolif. 2017. PMID 28990231.
• "Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression. ". J Immunol. 2017. PMID 28893956.
• "IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia. ". APMIS. 2017. PMID 28517553.
• "Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses. ". PLoS Pathog. 2016. PMID 27764250.
• "Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency.". J Virol. 2016. PMID 27466416.