HSPBP1

HSPBP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XQR, 1XQS
Dynodwyr
Cyfenwau	HSPBP1, FES1, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA (Hsp70) binding protein 1
Dynodwyr allanol	OMIM: 612939 HomoloGene: 40827 GeneCards: HSPBP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0048551 enzyme inhibitor activity • GO:0001948, GO:0016582 protein binding • adenyl-nucleotide exchange factor activity • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • Reticwlwm endoplasmig Prosesau biolegol • positive regulation of protein ubiquitination • protein folding • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0048553 negative regulation of catalytic activity • GO:0048552 regulation of catalytic activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23640	n/a
Ensembl	ENSG00000133265	n/a
UniProt	Q9NZL4	n/a
RefSeq (mRNA)	NM_001130106 NM_001297600 NM_012267	n/a
RefSeq (protein)	NP_001123578 NP_001284529 NP_036399	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSPBP1 yw HSPBP1 a elwir hefyd yn HSPA (Hsp70) binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.42.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSPBP1.

• FES1

Llyfryddiaeth

• "HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness. ". Cell Stress Chaperones. 2009. PMID 18987994.
• "Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. ". J Biol Chem. 2007. PMID 17855353.
• "HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression. ". Nucleic Acids Res. 2016. PMID 26538602.
• "Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1. ". Cell Stress Chaperones. 2014. PMID 24898092.
• "HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease.". J Neurochem. 2009. PMID 19183265.