HMGB2

HMGB2
Dynodwyr
Cyfenwau	HMGB2, HMG2, high mobility group box 2
Dynodwyr allanol	OMIM: 163906 HomoloGene: 37582 GeneCards: HMGB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • non-sequence-specific DNA binding, bending • single-stranded DNA binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • RAGE receptor binding • chemoattractant activity • double-stranded DNA binding • DNA binding, bending • supercoiled DNA binding • RNA binding • GO:0001105 transcription coactivator activity Cydrannau o'r gell • cytoplasm • nucleoplasm • Cromosom • extracellular region • nucleolus • perinuclear region of cytoplasm • condensed chromosome • cnewyllyn cell • extracellular space • GO:0009327 protein-containing complex Prosesau biolegol • DNA geometric change • positive regulation of interferon-beta production • nucleosome assembly • DNA recombination • apoptotic DNA fragmentation • male gonad development • GO:0009373 regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • positive regulation of erythrocyte differentiation • inflammatory response to antigenic stimulus • immune system process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • response to steroid hormone • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • negative regulation of gene expression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • chemotaxis • response to lipopolysaccharide • GO:1901313 positive regulation of gene expression • positive regulation of nuclease activity • GO:0051636 defense response to Gram-negative bacterium • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • V(D)J recombination • spermatogenesis • positive regulation of innate immune response • cell chemotaxis • DNA ligation involved in DNA repair • spermatid nucleus differentiation • positive regulation of DNA binding • innate immune response • GO:0045996 negative regulation of transcription, DNA-templated • cellular response to lipopolysaccharide • inflammatory response • positive regulation of megakaryocyte differentiation • regulation of neurogenesis • regulation of stem cell proliferation • DNA topological change • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0051637 defense response to Gram-positive bacterium • positive chemotaxis • chromatin remodeling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3148	n/a
Ensembl	ENSG00000164104	n/a
UniProt	P26583	n/a
RefSeq (mRNA)	NM_002129 NM_001130688 NM_001130689	n/a
RefSeq (protein)	NP_001124160 NP_001124161 NP_002120	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HMGB2 yw HMGB2 a elwir hefyd yn High mobility group box 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q34.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HMGB2.

• HMG2

Llyfryddiaeth

• "Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. ". Acta Biochim Biophys Sin (Shanghai). 2017. PMID 28069585.
• "HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci. ". J Cell Biol. 2016. PMID 27799366.
• "Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma. ". Proteomics. 2015. PMID 25327479.
• "High-mobility group box 2 is associated with prognosis of glioblastoma by promoting cell viability, invasion, and chemotherapeutic resistance. ". Neuro Oncol. 2013. PMID 23828241.
• "Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility.". Nucleic Acids Res. 2013. PMID 23143110.