HIRA

HIRA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I32
Dynodwyr
Cyfenwau	HIRA, DGCR1, TUP1, TUPLE1, histone cell cycle regulator
Dynodwyr allanol	OMIM: 600237 HomoloGene: 48172 GeneCards: HIRA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity • nucleosome binding • DNA binding Cydrannau o'r gell • PML body • extracellular exosome • cnewyllyn cell • nucleoplasm • HIR complex • chromosome, centromeric region • GO:0009327 protein-containing complex Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • muscle cell differentiation • anatomical structure morphogenesis • GO:0009373 regulation of transcription, DNA-templated • gastrulation • osteoblast differentiation • transcription, DNA-templated • negative regulation of nucleic acid-templated transcription • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7290	n/a
Ensembl	ENSG00000100084	n/a
UniProt	P54198	n/a
RefSeq (mRNA)	NM_003325	n/a
RefSeq (protein)	NP_003316	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HIRA yw HIRA a elwir hefyd yn Histone cell cycle regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HIRA.

• TUP1
• DGCR1
• TUPLE1

Llyfryddiaeth

• "Microduplication 22q11.2 in a child with autism spectrum disorder: clinical and genetic study. ". Dev Med Child Neurol. 2008. PMID 19046189.
• "Genomic organization of TUPLE1/HIRA: a gene implicated in DiGeorge syndrome. ". Mamm Genome. 1996. PMID 8995764.
• "HIRAGene is Lower Expressed in the Myocardium of Patients with Tetralogy of Fallot. ". Chin Med J (Engl). 2016. PMID 27748330.
• "Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA. ". Cell. 2013. PMID 24074863.
• "Placing the HIRA histone chaperone complex in the chromatin landscape.". Cell Rep. 2013. PMID 23602572.