GNRH1

GNRH1
Dynodwyr
Cyfenwau	GNRH1, GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone
Dynodwyr allanol	OMIM: 152760 MGI: 95789 HomoloGene: 641 GeneCards: GNRH1
Lleoliad y genyn (llygoedn) Cr. Cromosom 14 (llygoden) Band 14|14 D1 Start 67,745,181 bp End 67,749,439 bp
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • gonadotropin hormone-releasing hormone activity • gonadotropin-releasing hormone receptor binding Cydrannau o'r gell • axon terminus • perikaryon • Golgi-associated vesicle • extracellular region • neurosecretory vesicle • dendrite • Mitocondria • neuron projection • cytoplasmic side of rough endoplasmic reticulum membrane • extracellular space Prosesau biolegol • negative regulation of immature T cell proliferation • response to prolactin • negative regulation of neuron migration • response to potassium ion • response to organic cyclic compound • response to testosterone • estrous cycle • female pregnancy • cell-cell signaling • response to steroid hormone • heneiddio • response to peptide hormone • negative regulation of apoptotic process • male sex determination • multicellular organism development • response to prostaglandin E • response to lipopolysaccharide • response to corticosteroid • regulation of gene expression • ovulation cycle • response to ethanol • regulation of ovarian follicle development • signal transduction • negative regulation of cell proliferation • regulation of receptor activity • G-protein coupled receptor signaling pathway • Atgenhedlu Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2796	14714
Ensembl	ENSG00000147437	ENSMUSG00000015812
UniProt	P01148	P13562
RefSeq (mRNA)	NM_001083111 NM_000825	NM_008145
RefSeq (protein)	NP_000816 NP_001076580	NP_032171
Lleoliad (UCSC)	n/a	Chr : 67.75 – 67.75 Mb
PubMed search
Wicidata
Gweld/Golygu Bod dynol Gweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNRH1 yw GNRH1 a elwir hefyd yn Gonadotropin releasing hormone 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNRH1.

• GRH
• GNRH
• LHRH
• LNRH

Llyfryddiaeth

• "Enhanced therapeutic efficacy of LHRHa-targeted brucea javanica oil liposomes for ovarian cancer. ". BMC Cancer. 2016. PMID 27793127.
• "LHRH receptor expression in sarcomas of bone and soft tissue. ". Horm Mol Biol Clin Investig. 2016. PMID 27639272.
• "Complete Idiopathic Hypogonadotropic Hypogonadism due to Homozygous GNRH1 Mutations in the Mutational Hot Spots in the Region Encoding the Decapeptide. ". Horm Res Paediatr. 2016. PMID 26595427.
• "GnRH participates in the self-renewal of A549-derived lung cancer stem-like cells through upregulation of the JNK signaling pathway. ". Oncol Rep. 2015. PMID 25955300.
• "Gonadotropin-releasing hormone agonists sensitize, and resensitize, prostate cancer cells to docetaxel in a p53-dependent manner.". PLoS One. 2014. PMID 24722580.