GGA3

GGA3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8
Dynodwyr
Cyfenwau	GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
Dynodwyr allanol	OMIM: 606006 HomoloGene: 121703 GeneCards: GGA3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin binding Cydrannau o'r gell • endosome • trans-Golgi network • endosome membrane • intracellular anatomical structure • bilen • clathrin adaptor complex • Golgi apparatus • early endosome membrane • recycling endosome membrane • early endosome • recycling endosome Prosesau biolegol • protein transport • intracellular protein transport • GO:1903364 positive regulation of protein catabolic process • vesicle-mediated transport • protein localization to lysosome • regulation of protein stability • protein destabilization • endocytic recycling • protein localization to cell surface • Golgi to plasma membrane protein transport • negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23163	n/a
Ensembl	ENSG00000125447	n/a
UniProt	Q9NZ52	n/a
RefSeq (mRNA)	NM_001172703 NM_001172704 NM_001291641 NM_001291642 NM_014001 NM_138619	n/a
RefSeq (protein)	NP_001166174 NP_001166175 NP_001278570 NP_001278571 NP_054720 NP_619525	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GGA3 yw GGA3 a elwir hefyd yn Golgi associated, gamma adaptin ear containing, ARF binding protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.1.

Llyfryddiaeth

• "GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export. ". Mol Cell Biol. 2016. PMID 26811329.
• "GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. ". Mol Biol Cell. 2015. PMID 26446845.
• "Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3. ". Traffic. 2016. PMID 26935970.
• "Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. ". Neuron. 2007. PMID 17553422.
• "Predominant expression of the short form of GGA3 in human cell lines and tissues.". Biochem Biophys Res Commun. 2003. PMID 12810073.