FOXC1

FOXC1
Dynodwyr
Cyfenwau	FOXC1, ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3, forkhead box C1, ASGD3
Dynodwyr allanol	OMIM: 601090 HomoloGene: 20373 GeneCards: FOXC1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • DNA binding, bending; • transcription coactivator binding; • GO:0001105 transcription coactivator activity; • transcription factor binding; • promoter-specific chromatin binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • cytosol;
Prosesau biolegol	• eye development; • somitogenesis; • Notch signaling pathway; • skeletal system development; • glycosaminoglycan metabolic process; • positive regulation of hematopoietic progenitor cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • neural crest cell development; • paraxial mesoderm formation; • ossification; • vascular endothelial growth factor signaling pathway; • collagen fibril organization; • maintenance of lens transparency; • heart morphogenesis; • in utero embryonic development; • cardiac muscle cell proliferation; • lymph vessel development; • transcription, DNA-templated; • embryonic heart tube development; • positive regulation of hematopoietic stem cell differentiation; • odontogenesis of dentin-containing tooth; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • ventricular cardiac muscle tissue morphogenesis; • heart development; • blood vessel remodeling; • brain development; • vascular endothelial growth factor receptor signaling pathway; • negative regulation of lymphangiogenesis; • blood vessel development; • GO:1901313 positive regulation of gene expression; • mesenchymal cell differentiation; • mesenchymal cell development; • artery morphogenesis; • ovarian follicle development; • negative regulation of angiogenesis; • camera-type eye development; • regulation of organ growth; • germ cell migration; • lacrimal gland development; • negative regulation of mitotic cell cycle; • negative regulation of apoptotic process involved in outflow tract morphogenesis; • transcription by RNA polymerase II; • endochondral ossification; • cell population proliferation; • positive regulation of epithelial to mesenchymal transition; • cell migration; • positive regulation of DNA binding; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to epidermal growth factor stimulus; • positive regulation of core promoter binding; • GO:1901227 negative regulation of transcription by RNA polymerase II; • cerebellum development; • positive regulation of keratinocyte differentiation; • glomerular epithelium development; • ureteric bud development; • kidney development; • chemokine-mediated signaling pathway; • cellular response to chemokine; • angiogenesis; • multicellular organism development; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • anatomical structure morphogenesis; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	2296
	n/a
	ENSG00000054598
	n/a
	Q12948
	n/a
	NM_001453
	n/a
	NP_001444
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXC1 yw FOXC1 a elwir hefyd yn Forkhead box C1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p25.3.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXC1.

ARA
IGDA
IHG1
ASGD3
FKHL7
IRID1
RIEG3
FREAC3
FREAC-3

Llyfryddiaeth[golygu | golygu cod]

"FOXC1 overexpression is a marker of poor response to anthracycline-based adjuvant chemotherapy in sporadic triple-negative breast cancer. ". Cancer Chemother Pharmacol. 2017. PMID 28493031.
"FOXC1: an emerging marker and therapeutic target for cancer. ". Oncogene. 2017. PMID 28288141.
"Brachydactyly type E in an Italian family with 6p25 trisomy. ". Eur J Med Genet. 2017. PMID 28111183.
"The role and the potential regulatory pathways of high expression of forkhead box C1 in promoting tumor growth and metastasis of basal-like breast cancer. ". J BUON. 2016. PMID 27685901.
"A Novel Homozygous Mutation in FOXC1 Causes Axenfeld Rieger Syndrome with Congenital Glaucoma.". PLoS One. 2016. PMID 27463523.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] FOXC1 - Cronfa NCBI

[1]

[2]