FLI1

FLI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FLI, 1X66, 2YTU, 5E8G, 5E8I
Dynodwyr
Cyfenwau	FLI1, EWSR2, SIC-1, Fli-1 proto-oncogene, ETS transcription factor, BDPLT21, FLI-1
Dynodwyr allanol	OMIM: 193067 HomoloGene: 55624 GeneCards: FLI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • cytosol • nuclear body Prosesau biolegol • megakaryocyte development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • hemostasis • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cell differentiation • animal organ morphogenesis • blood circulation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2313	n/a
Ensembl	ENSG00000151702	n/a
UniProt	Q01543	n/a
RefSeq (mRNA)	NM_001167681 NM_001271010 NM_001271012 NM_002017	n/a
RefSeq (protein)	NP_001161153 NP_001257939 NP_001257941 NP_002008 NP_001161153.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLI1 yw FLI1 a elwir hefyd yn Friend leukemia virus integration 1, isoform CRA_c (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLI1.

• EWSR2
• SIC-1
• BDPLT21

Llyfryddiaeth

• "The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway. ". J Immunol. 2018. PMID 29141862.
• "Increased FLI-1 Expression is Associated With Poor Prognosis in Non-Small Cell Lung Cancers. ". Appl Immunohistochem Mol Morphol. 2016. PMID 26317314.
• "Overexpression of Fli-1 is associated with adverse prognosis of endometrial cancer. ". Cancer Invest. 2015. PMID 26305602.
• "Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer. ". Oncotarget. 2015. PMID 26156017.
• "FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression.". Neoplasia. 2014. PMID 25379017.