FGF2

FGF2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Dynodwyr
Cyfenwau	FGF2, BFGF, FGF-2, FGFB, HBGF-2, fibroblast growth factor 2
Dynodwyr allanol	OMIM: 134920 HomoloGene: 1521 GeneCards: FGF2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • heparin binding; • fibroblast growth factor receptor binding; • GO:0001948, GO:0016582 protein binding; • nuclear receptor coactivator activity; • chemoattractant activity; • growth factor activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • 1-phosphatidylinositol-3-kinase activity; • receptor-receptor interaction; • integrin binding;
Cydrannau o'r gell	• extracellular region; • cnewyllyn cell; • extracellular space;
Prosesau biolegol	• release of sequestered calcium ion into cytosol; • cell differentiation; • negative regulation of fibroblast migration; • hyaluronan catabolic process; • positive regulation of endothelial cell proliferation; • positive regulation of MAP kinase activity; • negative regulation of blood vessel endothelial cell migration; • positive regulation of endothelial cell chemotaxis to fibroblast growth factor; • somatic stem cell population maintenance; • positive regulation of phospholipase C activity; • extracellular matrix organization; • wound healing; • negative regulation of cell death; • regulation of angiogenesis; • nervous system development; • cell migration involved in sprouting angiogenesis; • MAPK cascade; • positive regulation of angiogenesis; • positive regulation of phosphatidylinositol 3-kinase activity; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • chemotaxis; • fibroblast growth factor receptor signaling pathway; • chondroblast differentiation; • multicellular organism development; • growth factor dependent regulation of skeletal muscle satellite cell proliferation; • branching involved in ureteric bud morphogenesis; • positive regulation of cardiac muscle cell proliferation; • embryonic morphogenesis; • angiogenesis; • positive regulation of cell fate specification; • animal organ morphogenesis; • regulation of endothelial cell chemotaxis to fibroblast growth factor; • phosphatidylinositol biosynthetic process; • inositol phosphate biosynthetic process; • negative regulation of wound healing; • Ras protein signal transduction; • positive regulation of cell division; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive chemotaxis; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • positive regulation of sprouting angiogenesis; • positive regulation of cell population proliferation; • phosphatidylinositol-3-phosphate biosynthetic process; • stem cell proliferation; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling; • cytokine-mediated signaling pathway; • positive regulation of blood vessel endothelial cell migration; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular endothelial cell proliferation; • positive regulation of cell migration involved in sprouting angiogenesis; • paracrine signaling; • positive regulation of DNA biosynthetic process; • positive regulation of endothelial cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologau
	2247
	n/a
	ENSG00000138685
	n/a
	P09038
	n/a
	NM_002006; NM_001361665
	n/a
	NP_001997; NP_001348594
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF2 yw FGF2 a elwir hefyd yn Fibroblast growth factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q28.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF2.

BFGF
FGFB
FGF-2
HBGF-2

Llyfryddiaeth[golygu | golygu cod]

"bFGFPolymorphism Is Associated with Disease Progression and Response to Chemotherapy in Multiple Myeloma Patients. ". Anticancer Res. 2017. PMID 28373444.
"Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration. ". Exp Cell Res. 2017. PMID 28363830.
"Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell-Airway Smooth Muscle Cell Communication through Membrane Conduits. ". J Immunol. 2017. PMID 28924004.
"siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells. ". Tumour Biol. 2017. PMID 28656882.
"Inhibition activity of a disulfide-stabilized diabody against basic fibroblast growth factor in lung cancer.". Oncotarget. 2017. PMID 28423625.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] FGF2 - Cronfa NCBI

[1]

[2]