FAS

FAS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DDF, 3EWT, 3EZQ, 3THM, 3TJE, 2NA7
Dynodwyr
Cyfenwau	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, Fas cell surface death receptor
Dynodwyr allanol	OMIM: 134637 HomoloGene: 27 GeneCards: FAS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • kinase binding • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • signal transducer activity • identical protein binding • tumor necrosis factor-activated receptor activity • tumor necrosis factor binding • calmodulin binding • signaling receptor activity Cydrannau o'r gell • CD95 death-inducing signaling complex • bilen • extracellular region • cell surface • extracellular exosome • integral component of membrane • Cellbilen • integral component of plasma membrane • external side of plasma membrane • death-inducing signaling complex • membrane raft • cytosol • nuclear body • mitocondria Prosesau biolegol • renal system process • activation-induced cell death of T cells • tumor necrosis factor-mediated signaling pathway • T cell homeostasis • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • cellular response to mechanical stimulus • Rhythm circadaidd • apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway via death domain receptors • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0097285 apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • spleen development • negative thymic T cell selection • regulation of lymphocyte differentiation • necroptotic signaling pathway • motor neuron apoptotic process • inflammatory response • regulation of myeloid cell differentiation • protein homooligomerization • response to toxic substance • B cell mediated immunity • neuron apoptotic process • positive regulation of protein homooligomerization • cellular response to lithium ion • positive regulation of lymphocyte apoptotic process • negative regulation of apoptotic process • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • gene expression • cellular response to hyperoxia • negative regulation of B cell activation • response to glucocorticoid • extrinsic apoptotic signaling pathway in absence of ligand • inflammatory cell apoptotic process • immunoglobulin production • GO:0072468 signal transduction • hepatocyte apoptotic process • response to lipopolysaccharide • extrinsic apoptotic signaling pathway • regulation of apoptotic process • positive regulation of apoptotic process • regulation of cell population proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • multicellular organism development • extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of protein phosphorylation • regulation of stress-activated MAPK cascade • cellular response to amino acid starvation • Fas signaling pathway • positive regulation of apoptotic signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	355	n/a
Ensembl	ENSG00000026103	n/a
UniProt	P25445	n/a
RefSeq (mRNA)	NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877 NM_001320619	n/a
RefSeq (protein)	NP_000034 NP_001307548 NP_690610 NP_690611	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FAS yw FAS a elwir hefyd yn Fas cell surface death receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FAS.

• APT1
• CD95
• FAS1
• APO-1
• FASTM
• ALPS1A
• TNFRSF6

Llyfryddiaeth

• "High Expression of Fas/CD95 on CD4+ Circulating T Cells: An Exclusion Criterion in the Diagnosis of Mycosis Fungoides?". Acta Derm Venereol. 2017. PMID 28206666.
• "Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer. ". Oncotarget. 2017. PMID 28121628.
• "Rare splicing defects of FAS underly severe recessive autoimmune lymphoproliferative syndrome. ". Clin Immunol. 2017. PMID 28668589.
• "CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage. ". Cell Death Dis. 2017. PMID 28300842.
• "FAS c.-671A>G polymorphism and cervical cancer risk: a case-control study and meta-analysis.". Cancer Genet. 2017. PMID 28279307.