FADD

FADD
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ
Dynodwyr
Cyfenwau	FADD, GIG3, MORT1, Fas associated via death domain, IMD90
Dynodwyr allanol	OMIM: 602457 HomoloGene: 2836 GeneCards: FADD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • identical protein binding • tumor necrosis factor receptor superfamily binding • death effector domain binding • caspase binding • GO:0001948, GO:0016582 protein binding • protease binding • death receptor binding • tumor necrosis factor receptor binding • receptor serine/threonine kinase binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytosol • membrane raft • ripoptosome • cell body • neuron projection • CD95 death-inducing signaling complex • Cellbilen • death-inducing signaling complex • cytoplasm • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • TRAIL-activated apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway via death domain receptors • motor neuron apoptotic process • immune system process • necroptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of necroptotic process • positive regulation of interleukin-8 production • positive regulation of type I interferon-mediated signaling pathway • cell surface receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • positive regulation of macrophage differentiation • defense response to virus • activation of cysteine-type endopeptidase activity • apoptotic signaling pathway • cellular response to mechanical stimulus • extrinsic apoptotic signaling pathway in absence of ligand • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • extrinsic apoptotic signaling pathway via death domain receptors • regulation of apoptotic process • death-inducing signaling complex assembly • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of tumor necrosis factor production • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0072468 signal transduction • positive regulation of proteolysis • GO:0022415 viral process • GO:0097285 apoptotic process • positive regulation of activated T cell proliferation • extrinsic apoptotic signaling pathway • positive regulation of T cell mediated cytotoxicity • positive regulation of extrinsic apoptotic signaling pathway • thymus development • positive regulation of adaptive immune response • T cell differentiation in thymus • innate immune response • spleen development • negative regulation of activation-induced cell death of T cells • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of interferon-gamma production • positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation • lymph node development • T cell homeostasis • adwaith i gocên • response to morphine • behavioral response to cocaine • regulation of necroptotic process • positive regulation of apoptotic process • toll-like receptor 3 signaling pathway • kidney development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8772	n/a
Ensembl	ENSG00000168040	n/a
UniProt	Q13158	n/a
RefSeq (mRNA)	NM_003824	n/a
RefSeq (protein)	NP_003815	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FADD yw FADD a elwir hefyd yn Fas associated via death domain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FADD.

• GIG3
• MORT1

Llyfryddiaeth

• "The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD). ". J Biol Chem. 2017. PMID 28860194.
• "Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample. ". Mol Neurodegener. 2017. PMID 28320441.
• "Clinical Implications of FADD Gene Amplification and Protein Overexpression in Taiwanese Oral Cavity Squamous Cell Carcinomas. ". PLoS One. 2016. PMID 27764170.
• "Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. ". Am J Physiol Endocrinol Metab. 2015. PMID 26419589.
• "Modulatory role of the anti-apoptotic protein kinase CK2 in the sub-cellular localization of Fas associated death domain protein (FADD).". Biochim Biophys Acta. 2015. PMID 26253696.