EPHB4

EPHB4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2BBA, 2E7H, 2QKQ, 2VWU, 2VWV, 2VWW, 2VWX, 2VWY, 2VWZ, 2VX0, 2VX1, 2X9F, 2XVD, 2YN8, 3ZEW, 4AW5, 4BB4, 2HLE
Dynodwyr
Cyfenwau	EPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD, CMAVM2, LMPHM7
Dynodwyr allanol	OMIM: 600011 HomoloGene: 20939 GeneCards: EPHB4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity • transmembrane-ephrin receptor activity Cydrannau o'r gell • integral component of membrane • cytosol • bilen • Cellbilen • integral component of plasma membrane • extracellular region • extracellular exosome • neuron projection • receptor complex Prosesau biolegol • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • heart morphogenesis • cell migration involved in sprouting angiogenesis • multicellular organism development • protein phosphorylation • cell adhesion • angiogenesis • protein autophosphorylation • peptidyl-tyrosine phosphorylation • ephrin receptor signaling pathway • axon guidance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2050	n/a
Ensembl	ENSG00000196411	n/a
UniProt	P54760	n/a
RefSeq (mRNA)	NM_004444	n/a
RefSeq (protein)	NP_004435	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHB4 yw EPHB4 a elwir hefyd yn EPH receptor B4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHB4.

• HTK
• MYK1
• HFASD
• TYRO11

Llyfryddiaeth

• "A rapid and sensitive method for EphB4 identification as a diagnostic and therapeutic biomarker in invasive breast cancer. ". J Cancer Res Ther. 2016. PMID 27072235.
• "EphB4 promotes the proliferation, invasion, and angiogenesis of human colorectal cancer. ". Exp Mol Pathol. 2016. PMID 27072105.
• "Overexpression of EPHB4 Is Associated with Poor Survival of Patients with Gastric Cancer. ". Anticancer Res. 2017. PMID 28739744.
• "EPHB4, a down stream target of IFN-γ/STAT1 signal pathway, regulates endothelial activation possibly contributing to the development of preeclampsia. ". Am J Reprod Immunol. 2016. PMID 27553867.
• "EphB4/ephrinB2 Contributes to Imatinib Resistance in Chronic Myeloid Leukemia Involved in Cytoskeletal Proteins.". Int J Med Sci. 2016. PMID 27226777.