EIF4EBP1

EIF4EBP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EJ4, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV
Dynodwyr
Cyfenwau	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E binding protein 1
Dynodwyr allanol	OMIM: 602223 HomoloGene: 3021 GeneCards: EIF4EBP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • translation repressor activity • GO:0001948, GO:0016582 protein binding • eukaryotic initiation factor 4E binding • translation initiation factor binding • protein phosphatase 2A binding Cydrannau o'r gell • cytosol • cytoplasm • cnewyllyn cell • GO:0009327 protein-containing complex • glutamatergic synapse • postsynaptic cytosol Prosesau biolegol • negative regulation of translation • negative regulation of translational initiation • positive regulation of mitotic cell cycle • TOR signaling • IRES-dependent translational initiation of linear mRNA • regulation of translation • GO:1901047 insulin receptor signaling pathway • cellular response to dexamethasone stimulus • G1/S transition of mitotic cell cycle • response to ischemia • lung development • GO:0106160 negative regulation of protein-containing complex assembly • response to ethanol • cellular response to hypoxia • response to amino acid starvation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1978	n/a
Ensembl	ENSG00000187840	n/a
UniProt	Q13541	n/a
RefSeq (mRNA)	NM_004095	n/a
RefSeq (protein)	NP_004086	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4EBP1 yw EIF4EBP1 a elwir hefyd yn Eukaryotic translation initiation factor 4E binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p11.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4EBP1.

• BP-1
• 4EBP1
• 4E-BP1
• PHAS-I

Llyfryddiaeth

• "Increased phosphorylation of 4E‑binding protein 1 predicts poor prognosis for patients with colorectal cancer. ". Mol Med Rep. 2017. PMID 28339030.
• "Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. ". Cancer Lett. 2016. PMID 27343979.
• "Phosphorylated 4EBP1 is associated with tumor progression and poor prognosis in Xp11.2 translocation renal cell carcinoma. ". Sci Rep. 2016. PMID 27026382.
• "4E-BP1, a multifactor regulated multifunctional protein. ". Cell Cycle. 2016. PMID 26901143.
• "Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.". Sci Signal. 2015. PMID 26577921.