EIF4E2

EIF4E2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JGB, 2JGC
Dynodwyr
Cyfenwau	EIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
Dynodwyr allanol	OMIM: 605895 HomoloGene: 128466 GeneCards: EIF4E2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • RNA cap binding • translation factor activity, RNA binding • GO:0001948, GO:0016582 protein binding • translation initiation factor activity • ubiquitin protein ligase binding • RNA binding • RNA 7-methylguanosine cap binding Cydrannau o'r gell • cytoplasm • cytosol • mRNA cap binding complex • eukaryotic translation initiation factor 4F complex Prosesau biolegol • translational initiation • negative regulation of translation • in utero embryonic development • protein biosynthesis • regulation of translation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9470	n/a
Ensembl	ENSG00000135930	n/a
UniProt	O60573	n/a
RefSeq (mRNA)	NM_001276336 NM_001276337 NM_001282958 NM_004846 NM_001330201 NM_001330202 NM_001330203	n/a
RefSeq (protein)	NP_001263265 NP_001263266 NP_001269887 NP_001317130 NP_001317131 NP_001317132 NP_004837	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4E2 yw EIF4E2 a elwir hefyd yn Eukaryotic translation initiation factor 4E family member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q37.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4E2.

• 4EHP
• IF4e
• 4E-LP
• h4EHP
• EIF4EL3

Llyfryddiaeth

• "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. ". J Biol Chem. 1998. PMID 9582349.
• "Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs. ". Mol Cell Biol. 2015. PMID 26370510.
• "MicroRNAs recruit eIF4E2 to repress translation of target mRNAs. ". Protein Cell. 2017. PMID 28755203.
• "Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression. ". Cancer Res. 2014. PMID 24408918.
• "Weak binding affinity of human 4EHP for mRNA cap analogs.". RNA. 2007. PMID 17369309.