E2F4

E2F4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CF7
Dynodwyr
Cyfenwau	E2F4, E2F-4, E2F transcription factor 4
Dynodwyr allanol	OMIM: 600659 HomoloGene: 1471 GeneCards: E2F4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • promoter-specific chromatin binding • protein dimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding Cydrannau o'r gell • transcription regulator complex • nucleoplasm • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • regulation of cell size • epithelial cell development • cell volume homeostasis • GO:0009373 regulation of transcription, DNA-templated • multi-ciliated epithelial cell differentiation • transcription by RNA polymerase II • regulation of transcription involved in G1/S transition of mitotic cell cycle • blood circulation • cell projection organization • regulation of cell population proliferation • animal organ morphogenesis • cell cycle • motile cilium assembly • centriole assembly • transcription, DNA-templated • GO:0007067 Mitosis • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cilium assembly • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1874	n/a
Ensembl	ENSG00000205250	n/a
UniProt	Q16254	n/a
RefSeq (mRNA)	NM_001950	n/a
RefSeq (protein)	NP_001941	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn E2F4 yw E2F4 a elwir hefyd yn Transcription factor E2F4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn E2F4.

• E2F-4

Llyfryddiaeth

• "[E2F4 as susceptibility factor in the early onset colorectal cancer]. ". Med Clin (Barc). 2016. PMID 26343152.
• "Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4. ". Int J Oncol. 2013. PMID 24100580.
• "E2F4 plays a key role in Burkitt lymphoma tumorigenesis. ". Leukemia. 2012. PMID 22475873.
• "E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. ". J Cell Physiol. 2009. PMID 19562678.
• "Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells.". Am J Physiol Gastrointest Liver Physiol. 2007. PMID 17656449.